[Multi-centered, randomized controlled clinical study on Chinese medicine formula particles for hyperlipidaemia associated with highly active antiretroviral therapy].

OBJECTIVE: To observe the effect and safety of Xiaozhi particles, integrated taohong Siwu tang and Erchen tang and Xuezhikang capsule in treating hyperlipidaemia (HLP) associated with highly active antiretroviral therapy (HAART). METHOD: In the multi-centered, randomized controlled clinical study, 180 hyperlipidaemia associated with highly active antiretroviral therapy cases were divided into the treatment group treated by Xiaozhi particles, integrated Taohong Siwu tang and Erchen tang, and the control group treated by Xuezhikang capsule. The treatment course was 12 weeks. The total cholesterol (Tch), triglyceride (TG), low density lipoprotein (LDL) and high-density lipoprotein(HDL) were observed. RESULT: After 12 weeks, compared with Xuezhikang capsule, the change difference of Tch, LDL, HDL in the Chinese traditional medicine formula groups of patients is significant (P < 0.05), the change of the TG has no significant difference. The effect of Tch, LDL in Xuezhikang capsule groups is better than in traditional Chinese medicine formula group,but the effect of HDL in traditional Chinese medicine formula group is better than in Xuezhikang capsule groups. CONCLUSION: Integrated Taohong Siwu tang and Erchen tang, Xiaozhi particles and Xuezhikang capsule can be used to control the hyperlipidaemia associated with highly active antiretroviral therapy as one of the main Chinese native medicine preparation.

[Inhibition of sulfite oxidation catalyzed by heavy metals in dual alkali flue gas desulfurization slurry].

Heavy metals accumulated in slurry of dual alkali flue gas desulfurization (FGD) present a significant catalysis to SO3(2-) oxidation, resulting in a waste of effective components for desulfurization. Na2S was adopted to precipitate heavy metal ions in FGD slurry, and the oxidation rate of SO3(2-) was obtained under different concentrations of heavy metal ions, to reveal the inhibition effect of Na2S on SO3(2-) oxidation catalyzed by heavy metal ions. Mn2+ showed a remarkable catalysis to SO3(-2) oxidation, as the initial oxidation rate of SO3(2-) was tripled to 0.65 mmol/(L x min) by adding 1.0 mmol/L Mn2+ into the slurry. SO3(2-) was catalytically oxidized rapidly with the reaction order 0.169 of Mn2+ within first 60 minutes, so it is of great importance to control the concentration of Mn2+ to inhibit SO3(2-) oxidation. At initial pH value of 6.50-8.50, Na2S removed heavy metal ions effectively from FGD slurry. Higher pH value favored the removal of heavy metal ions. The removal efficiencies of Mn2+, Zn2+, Ni2+ and Cd2+ were 91.0%, 88.1%, 85.5%, and above 99.9% respectively under the conditions of initial pH value 8.50 and Na2S dosage 240.0 mg/L. Mn2+ could be used as an indicator for the concentration of the heavy metal ions in the slurry. As the Mn2+ concentration decreased from 1.0 mmol/L to 5.0 x 10(-3) mmol/L by adding Na2S, the initial oxidation rate of SO3(2-) decreased by 64.6% to 0.23 mmol/(L x min). The desulfurization efficiencies increase 3.8%-5.1% by adding Na2S in a pilot scale setup. It comes to conclusion that heavy metal ions precipitation by adding Na2S with an indicator of Mn2+ to inhibit catalytic oxidation of SO3(2-) is feasible to reduce the consumption of desulfurizer in FGD slurry.