Prevalence and coping of depression and anxiety among college students during COVID-19 lockdowns in China.

BACKGROUND: This study sought to investigate the prevalence of anxiety, depression and mixed anxiety-depression disorder among college students during COVID-19 shelter-in-place lockdowns in China. METHODS: Participants (N = 2818) were selected from 8 provincial regions across the country in areas that were under lockdown mandates. The dependent variables were anxiety and depression. Multiple regression models were tested using anxiety and depression as the respective outcome variables, and binary logistic regression was conducted with anxiety-depression comorbidity as the dependent variable. Explanatory variables were changes in (social) media use and communication behaviors, perceived effectiveness of daily activity involvements as well as a number of demographic and environmental factors. RESULTS: Being a college senior, prior anxiety/depression history, having family members and residents in neighborhood tested positive with COVID were all important predictors of elevated anxiety, depression and their comorbidity. Increased face-to-face family communication and reading more e-books were associated with reduced anxiety, depression and their comorbidity. Listening to music and playing video games were correlated with lower anxiety but not depression. CONCLUSIONS: Draconian shelter-in-place lockdowns as strictly enforced in China within a short notice could be detrimental to individual mental health and psychological well-being. Findings in this research can provide practical guidance for college counselors and health professionals in targeting particular segments of the student population in providing tailored psychological, therapeutic and material services during disruptive moments and public health crises. The central role of family communication in the emotional and social support process deserves critical contemplation.

Differences in gene expression and variable splicing events of ovaries between large and small litter size in Chinese Xiang pigs.

BACKGROUND: Although lots of quantitative trait loci (QTLs) and genes present roles in litter size of some breeds, the information might not make it clear for the huge diversity of reproductive capability in pig breeds. To elucidate the inherent mechanisms of heterogeneity of reproductive capability in litter size of Xiang pig, we performed transcriptome analysis for the expression profile in ovaries using RNA-seq method. RESULTS: We identified 1,419 up-regulated and 1,376 down-regulated genes in Xiang pigs with large litter size. Among them, 1,010 differentially expressed genes (DEGs) were differently spliced between two groups with large or small litter sizes. Based on GO and KEGG analysis, numerous members of genes were gathered in ovarian steroidogenesis, steroid biosynthesis, oocyte maturation and reproduction processes. CONCLUSIONS: Combined with gene biological function, twelve genes were found out that might be related with the reproductive capability of Xiang pig, of which, eleven genes were recognized as hub genes. These genes may play a role in promoting litter size by elevating steroid and peptide hormones supply through the ovary and facilitating the processes of ovulation and in vivo fertilization.