RESUMO
Diagnosing asymptomatic neurosyphilis (ANS) in HIV-infected patients is difficult. A recent report suggested that CXCL13 is a promising diagnostic marker for neurosyphilis in HIV-positive patients. However, whether CXCL13 can be a diagnostic marker for ANS in HIV-infected patients remains unknown. The purpose of our study was to determine the role of CXCL13 in diagnosing ANS in HIV-infected patients. This study comprised two study and three control groups. Two study groups included 12 HIV-infected patients with ANS and 25 patients with syphilis and HIV co-infection (without ANS). Three control groups included 9 patients with ANS without HIV infection, 25 HIV-infected patients without syphilis and 10 healthy volunteers. Concentrations of CSF CXCL13 were measured before and after neurosyphilis therapy. Our results showed that CSF CXCL13 concentrations were significantly increased in all of the HIV-infected patients with ANS, the 25 HIV patients with syphilis and the 9 ANS patients without HIV, but not in the patients of the other two control groups. CSF CXCL13 concentrations declined in the two study groups of patients following neurosyphilis therapy. Therefore, CSF CXCL13 concentrations could improve the diagnosis of ANS in HIV-infected patients.
Assuntos
Quimiocina CXCL13/líquido cefalorraquidiano , Infecções por HIV/complicações , Neurossífilis/líquido cefalorraquidiano , Neurossífilis/diagnóstico , Treponema pallidum/isolamento & purificação , Adulto , Antitreponêmicos/uso terapêutico , Biomarcadores/líquido cefalorraquidiano , Cardiolipinas , Estudos de Casos e Controles , Líquido Cefalorraquidiano/citologia , Líquido Cefalorraquidiano/microbiologia , Proteínas do Líquido Cefalorraquidiano/metabolismo , Quimiocina CXCL13/metabolismo , Colesterol , Coinfecção , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neurossífilis/tratamento farmacológico , Fosfatidilcolinas , RNA Viral/sangue , RNA Viral/líquido cefalorraquidiano , Sensibilidade e Especificidade , Punção Espinal , Sífilis/diagnóstico , Sífilis/tratamento farmacológico , Sorodiagnóstico da Sífilis , Resultado do Tratamento , Treponema pallidum/imunologiaRESUMO
OBJECTIVE: To explore the relationship between psychological distress and T lymphocyte counts in HIV/AIDS patients. METHODS: A total of 102 HIV/AIDS patients were measured by symptom check list (SCL-90), self-rating depressive scale (SDS) and self-rating anxiety scale (SAS). Patients were divided into 2 groups based on CD4+ T lymphocyte counts < 0.2 x 10(9)/L (group A) and > or = 0.2 x 10(9)/L(group B). RESULTS: 77 cases (75.49%) had psychological problems, including depression, relationship problems, psychosis, force etc. The prevalence of depression and anxiety were 67.65% (69/102) and 43.13% (44/102) respectively. The symptom of depression and anxiety of patients in group A were severer than those in group B (P < 0.05). The CD4+ T lymphocyte counts were significantly negatively correlated with the total score, depression score, paranoid score and psychosis score of SCL-90 (all P <0.05). CONCLUSION: Most of the HIV/AIDS patients were in an obviously abnormal psychological status. The psychological distress symptom of HIV/AIDS patients might had negative effects on the number of CD4+ T lymphocyte.
