RESUMO
Four new compounds, compounds 1, 2, 4, 6, along with two known compounds 3, 5, were isolated from the methanol extract of the fruiting body of Neoboletus magnificus. The structures of compounds were elucidated by HRMS and NMR spectroscopic methods. The in vitro anti-inflammatory activity of the isolated compounds was evaluated.
Assuntos
Anti-Inflamatórios/isolamento & purificação , Basidiomycota/química , Anti-Inflamatórios/química , Carpóforos/química , Espectroscopia de Ressonância Magnética , Estrutura MolecularRESUMO
Three unprecedented indole alkaloids, trigonoliimines A-C (1-3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang. The structures of 1-3 were determined by the spectroscopic, computational, and CD exciton chirality approaches. Trigonoliimine A showed modest anti-HIV-1 activity (EC(50) = 0.95 microg/mL, TI = 7.9).
Assuntos
Fármacos Anti-HIV/isolamento & purificação , Euphorbiaceae/química , Alcaloides Indólicos/isolamento & purificação , Fármacos Anti-HIV/química , Fármacos Anti-HIV/farmacologia , HIV-1/efeitos dos fármacos , Alcaloides Indólicos/química , Alcaloides Indólicos/farmacologia , Testes de Sensibilidade Microbiana , Conformação Molecular , Folhas de Planta/química , EstereoisomerismoRESUMO
Three types with six new carboline alkaloids, trigonostemonines A-F (1- 6), were isolated from the roots and stems of Trigonostemon lii. Their structures were elucidated by spectroscopic analyses. It is the first time that beta-carboline alkaloids have been reported in Trigonostemon species. Trigonostemonine F (6) exhibited moderate cytotoxic activity against HL-60 with an IC (50) value of 16 microM.
Assuntos
Alcaloides/isolamento & purificação , Carbolinas/isolamento & purificação , Euphorbiaceae/química , Alcaloides/química , Carbolinas/química , Ensaios de Seleção de Medicamentos Antitumorais , Células HL-60 , Humanos , Análise Espectral/métodosRESUMO
Two new norbisabolane sesquiterpenoid glycosides, glochicoccinosides A (1) and B (2), together with two known compounds, have been isolated from the rhizomes of Glochidion coccineum. Their structures were elucidated by the combination of 1D NMR, 2D NMR, and MS spectral analysis, as well as chemical evidence. Cytotoxic activities and the antioxidant effect of these compounds were evaluated, but none of them showed activity.
Assuntos
Glicosídeos/química , Magnoliopsida/química , Sesquiterpenos/química , Estrutura MolecularRESUMO
Two novel chalcone constituents, tarennane (1) and tarennone (2), together with nine known compounds, were isolated from the whole plant of Tarenna attenuata. By analysis of physical and spectroscopic data, the structures of new compounds were elucidated as (E)-4-[3-(4-hydroxy-3-methoxyphenyl)-acryl]-3,4,5-trimethoxycyclohexa-2,5-dienone (1) and 1,2-bis(3,5-dimethoxy-4-hydroxyphenyl)-3-hydroxypropan-1-one (2). These two compounds were tested for antioxidant activities in the MTT and DPPH assays. Compound 1 revealed potent antioxidant activities against H2O2-induced impairment in PC12 cells, but neither of them showed DPPH radical-scavenging activity with IC50 values of 181.1 and 210.3 microM, respectively.
