RESUMO
Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-ß (TGF-ß) is a cytokine that has both protumor and antitumor activities, depending on tumor microenvironment. The interaction between TGF-ß signaling and the tumor microenvironment in PC is complex. Here, we reviewed the role of TGF-ß in the tumor microenvironment of PC, highlighting producers of TGF-ß and TGF-ß responders in the tumor microenvironment of PC.
RESUMO
In order to obtain the candidate strains of deodorizing microorganism, three optimization strains with relatively higher deodorizing capacity were isolated from landfill leachate, which were given the labels of CC3, CC7, CC13 and CC16. According to the results of morphological observation, physiological and biochemical tests, 16S rDNA sequence homology analysis, the strains CC3, CC7, CC13 and CC16 were identified as Pediococcus acidilactici, Bacillus megaterium, Lactobacillus acidophilus and Alcaligenes faecalis respectively. When the strains CC7, CC13 and CC16 were mixed with the inoculation rate was 1:1.5:0.5, the removal rates of ammonia and hydrogen sulfide were 83.56% and 70.25%. The optimal conditions of deodorizing by single factor test were deodorization time of 60 hours, sausage of 5%, temperature of 30 degrees C, initial pH of 6.5.