Self-strengthening and conductive cellulose composite hydrogel for high sensitivity strain sensor and flexible triboelectric nanogenerator.

Triboelectric nanogenerators (TENGs) as promising energy harvesting devices have gained increasing attention. However, the fabrication of TENG simultaneously meets the requirements of green start feedstock, flexible, stretchable, and environmentally friendly remains challenging. Herein, the hydroxyethyl cellulose macromonomer (HECM) simultaneously bearing acrylate and hydroxyl groups was first synthesized and used as a crosslinker to prepare the chemically and physically dual-crosslinked cellulose composite hydrogel for an electrode material of stretchable TENG. Meanwhile, the in-situ polymerization of pyrrole endowed the hydrogel with satisfactory conductivity of 0.40 S/m. More impressively, the synergies of the cellulose rigid skeleton and the construction of the dual-crosslinking network significantly improved the mechanical toughness, and the hydrogel exhibited excellent self-strengthening through cyclic compression mechanical training, the self-strengthening efficiency reached 124.7 % after 10 compression cycles. Given these features, the hydrogel was used as wearable strain sensors with extremely high sensitivity (GF = 3.95) for real-time monitoring human motions. Additionally, the hydrogel showed practical applications in stretchable H-TENG for converting mechanical energy into electric energy to light LEDs and power a digital watch, and in self-powered wearable sensors to distinguish human motions and English letters. This work provided a promising strategy for fabricating sustainable, eco-friendly energy harvesting and self-powered electronic devices.

Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins.

We report here the identification and characterization of a novel gene (AUTS2) that spans the 7q11.2 breakpoint in a monozygotic twin pair concordant for autism and a t(7;20) (q11.2; p11.2) translocation. AUTS2 is 1.2 Mb and has 19 exons. The predicted protein is 1295 amino acids and does not correspond to any known protein. DNA sequence analysis of autism subjects and controls revealed 22 biallelic polymorphic sites. For all sites, both alleles were observed in both cases and controls. Thus no autism-specific mutation was observed. Association analysis with two exonic polymorphic sites and linkage analysis of four dinucleotide repeat markers, two within and two flanking AUTS2, was negative. Thus, although it is unlikely that AUTS2 is an autism susceptibility gene for idiopathic autism, it may be the gene responsible for the disorder in the twins studied here.