1.
Org Lett
; 22(14): 5375-5379, 2020 Jul 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32589436
RESUMO
The Pd-catalyzed asymmetric [4+2] cycloaddition reaction of an aliphatic 1,4-dipole with singly activated electron-deficient alkenes is realized for the first time, enabled by using a newly developed benzylic substituted P,N-ligand, affording tetrahydropyrans having three continuous chiral centers in high yields with high diastereo- and enantioselectivities. The rational transition states of the reaction as well as the role of the benzylic chiral center are proposed.