1.
Org Biomol Chem
; 22(26): 5385-5392, 2024 Jul 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38869462
RESUMO
A copper-catalyzed syn-hydrocarbonization of internal alkynes with N,N-dimethylformamide dimethylacetal and silanes has been disclosed that offers an efficient and expedient access to (E)-α,ß-unsaturated aldehydes. This highly selective process, which can be performed at gram-scale, enjoys operational simplicity, as well as syngas-free conditions.