Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial.

Alzheimer's disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65-80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved.

Distribution and potential ecological risks of microplastics in Zhushan Bay, China.

The interaction between microplastics (MPs) and microorganisms may alter the distribution of antibiotic resistance genes (ARGs) in water and increase the ecological risk of drinking water sources. To investigate the characteristics of MPs geographical distribution and its potential ecological risk in typical urban water, this study was conducted in Zhushan Bay, and we carried out a combination of tests to analyze the distribution of MPs and the migration changes of their surface microbial community composition and ARGs in different media by 16S rRNA gene high-throughput sequencing, non-targeted metabolomics and qPCR genomics in the near-shore (I), middle area (Ⅱ) and near-lake (Ⅲ) of Zhushan Bay. The results showed that MPs in fibrous form were dominant in the aquatic environment of Zhushan Bay; Polyurethane (PU) and Silicone were the main MPs types in Zhushan Bay. The abundance of MPs in the water of Zhushan Bay was winter > summer > autumn > spring; and in the sediment was winter > summer > autumn > spring, respectively. The distribution results of MPs in geographical location are as follows: In the water I > â…¡ > â…¢, sediment exhibited Ⅱ > â…¢ > I. The results indicate that physicochemical factors will affect the geographical distribution of MPs and their surface microbial community composition in the aquatic environment of Zhushan Bay. More cooperative behaviors and increased metabolically important pathways occurred in the microbial network on water-MPs compared to sediment-MPs. However, the microbial community in the sediment-MPs was more stable and had higher abundance of mobile genetic elements (MGEs). A total of 362 differential metabolites were detected, of which 193 were up-regulated and 19 down-regulated differential metabolites. blaTEM, Sul, and inti1 were prevalent in both the water and sediments of Zhushan Bay. Sul1 was most contaminated in ARGs. This study provides the latest field data and insights into MPs pollution in key aquatic environments.

Transcriptomic analysis of the effect of deferoxamine exposure on the growth, photosynthetic activity and iron transfer of Microcystis aeruginosa.

Deferoxamine (DFB) is a trihydroxamic acid siderophore that chelates with iron (Fe) to form iron-siderophore complexes. The existence of siderophores in nature changes the form of iron and affects the absorption and utilization of iron by organisms. However, the relationship between siderophores and the growth of Cyanobacteria is largely unknown. In this study, the cellular and transcriptomic responses to the addition of DFB were investigated. A high concentration of DFB (12 mg/L) significantly inhibited the growth of Cyanobacteria cells, reduced photosynthetic activity, and induced the production of peroxidase, with the highest inhibition rate of algal growth of 74.82%. These indexes were also affected for the low (3 mg/L) and medium concentration (6 mg/L) groups, but this difference is closely related to the growth stage of Cyanobacteria cells. This may be due to competition between the cell-associated iron-binding part/system and the extracellular Fe (Ⅲ)-DFB ligand. Transcriptome results showed that most of the genes involved in iron uptake and transport were down-regulated, and only the fur gene encoding the iron uptake regulator protein was significantly up-regulated. Most genes related to photosynthesis, glycolysis, and fatty acid metabolism were also down-regulated, while the obvious up-regulation of a few genes may be a complex regulation in response to the down-regulation of most genes. These findings will provide important insights into the effects of siderophores on iron bioavailability in algae.

Potential mechanism of humic acid attenuating toxicity of Pb2+ and Cd2+ in Vallisneria natans.

Humic substances are widely present in aquatic environments. Due to the high affinity of humic substances for metals, the interactions have been particularly studied. To assess the effect of humic acid (HA) on submerged macrophytes and biofilms exposed to heavy metal stress, Vallisneria natans was exposed to solutions containing different concentrations of HA (0.5-2.0 mg·L-1), Pb2+ (1 mg·L-1) and Cd2+ (1 mg·L-1). Results suggested that HA positively affected the plant growth and alleviated toxicity by complexing with metals. HA increased the accumulation of metals in plant tissues and effectively induced antioxidant responses and protein synthesis. It was also noted that the exposure of HA and metals promoted the abundance and altered the structure of microbial communities in biofilms. Moreover, the positive effects of HA were considered to be related to the expression of related genes resulting from altered DNA methylation levels, which were mainly reflected in the altered type of demethylation. These results demonstrate that HA has a protective effect against heavy metal stress in Vallisneria natans by inducing effective defense mechanisms, altering biofilms and DNA methylation patterns in aquatic ecosystems.

Overview of deep learning based pedestrian attribute recognition and re-identification.

Pedestrian attribute recognition (PAR) and re-identification (ReID) are important works in the area of computer vision, which are widely used in intelligent surveillance and are of great significance to the creation of smart life. The purpose of this article is to focus on organizing a review of ReID based on deep learning and analyze the associations between PAR and ReID. Firstly, we summarize the major ideas of Attribute-Assisted ReID and compare the differences in datasets and algorithmic concerns between the two areas. Secondly, we introduce a wide range of representative ReID methods. By analyzing some cutting-edge researches, we summarize their specific network structure, loss function design, and effective training tricks. Reference methods and solutions are provided for the main challenges of ReID, such as cloth-changing, domain adaptation, occlusion condition, resolution changes, etc. Finally, we conclude the performance and characteristics of the SOTA methods, obtain inspiration and prospects for future research directions, and demonstrate the effectiveness of Attribute-Assisted ReID.

Satellite-derived bathymetry based on machine learning models and an updated quasi-analytical algorithm approach.

Retrieving the water depth by satellite is a rapid and effective method for obtaining underwater terrain. In the optical shallow waters, the bottom signal has a great impact on the radiation from the water which related to water depth. In the optical shallow waters, the spatial distribution characteristic of water quality parameters derived by the updated quasi analysis algorithm (UQAA) is highly correlated with the bottom brightness. Because the bottom reflection signal is strongly correlated with the spatial distribution of water depth, the derived water quality parameters may helpful and applicable for optical remote sensing based satellite derived bathymetry. Therefore, the influence on bathymetry retrieval of the UQAA IOPs is worth discussing. In this article, different machine learning algorithms using a UQAA were tested and remote sensing reflectance at water depth in situ points and their detection accuracy were evaluated by using Worldwiew-2 multispectral remote sensing images and laser measurement data. A backpropagation (BP) neural network, extreme value learning machine (ELM), random forest (RF), Adaboost, and support vector regression (SVR) machine models were utilized to compute the water depth retrieval of Ganquan Island in the South China Sea. According to the obtained results, bathymetry using the UQAA and remote sensing reflectance is better than that computed using only remote sensing reflectance, in which the overall improvements in the root mean square error (RMSE) were 1 cm to 5 cm and the overall improvement in the mean relative error (MRE) was 1% to 5%. The results showed that the results of the UQAA could be used as a main water depth estimation eigenvalue to increase water depth estimation accuracy.

Precise detection of water surface through the analysis of a single green waveform from bathymetry LiDAR.

Determination of the correct water surface height (WSH) from green laser (532 nm) echoes alone in bathymetry LiDAR is challenging, as the green laser return near the water surface involves both specular reflection from the air-water interface and backscattered return from the water volume. In this paper, a low-complexity method based on linear approximation of the leading edge (LLE) is proposed. The results of this LLE method were compared with those of three common algorithms of peak detection, half peak power, and surface-volume-bottom implemented on airborne datasets with various surface roughness conditions. In addition, the method was evaluated in waters with a wide range of optical properties through a controllable tank experiment. The uncertainties in the WSHs of all algorithms were greater when the water volume backscattering dominated the surface return; they were sensitive to variations in the optical properties of water, and increased exponentially with decreasing LiDAR attenuation coefficient (KLiDAR). Comparatively, the LLE algorithm had the fastest computational speed and demonstrated the best performance in situations where specular reflection or volume backscatter return was dominant, with average and maximum errors of less than 0.06 and 0.13 m, respectively.

Automatic detection of suspected sewage discharge from coastal outfalls based on Sentinel-2 imagery.

Terrestrial pollution has a great impact on the coastal ecological environment, and widely distributed coastal outfalls act as the final gate through which pollutants flow into rivers and oceans. Thus, effectively monitoring the water quality of coastal outfalls is the key to protecting the ecological environment. Satellite remote sensing provides an attractive way to monitor sewage discharge. Selecting the coastal areas of Zhejiang Province, China, as an example, this study proposes an innovative method for automatically detecting suspected sewage discharge from coastal outfalls based on high spatial resolution satellite imageries from Sentinel-2. According to the accumulated in situ observations, we established a training dataset of water spectra covering various optical water types from satellite-retrieved remote sensing reflectance (Rrs). Based on the clustering results from unsupervised classification and different spectral indices, a random forest (RF) classification model was established for the optical water type classification and detection of suspected sewage. The final classification covers 14 optical water types, with type 12 and type 14 corresponding to the high eutrophication water type and suspected sewage water type, respectively. The classification result of model training datasets exhibited high accuracy with only one misclassified sample. This model was evaluated by historical sewage discharge events that were verified by on-site observations and demonstrated that it could successfully recognize sewage discharge from coastal outfalls. In addition, this model has been operationally applied to automatically detect suspected sewage discharge in the coastal area of Zhejiang Province, China, and shows broad application value for coastal pollution supervision, management, and source analysis.

Forward volume scattering function (0.03°-60°) measured using an oblique-incidence particle sizer.

The forward volume scattering function (VSF) is an inherent optical property important in ocean lidar and underwater imaging and communication. The scattered power within 60° contains >90% of total scattered power, making it essential for determining the asymmetry parameter g. Thus, the new oblique-incidence-design Bettersize BT-3000 particle sizer was utilized to measure forward VSF (0.03°-60°) synchronously. A double-exponential model was then used to construct the full-angle-range VSF (0°-180°). The g value calculated therefrom had an uncertainty of <1%. Calibration was implemented using 11-µm beads alone, and the BT-3000's performance was validated.

Investigating impact of cardiorespiratory fitness in reducing brain tissue loss caused by ageing.

Mitigating the loss of brain tissue due to age is a major problem for an ageing population. Improving cardiorespiratory fitness has been suggested as a possible strategy, but the influenceon brain morphology has not been fully characterized. To investigate the dependent shifts in brain tissue distribution as a function of cardiorespiratory fitness, we used a 3D transport-based morphometry approach. In this study of 172 inactive older adults aged 58-81 (66.5 ± 5.7) years, cardiorespiratory fitness was determined by V O 2 peak (ml/kg/min) during graded exercise and brain morphology was assessed through structural magnetic resonance imaging. After correcting for covariates including age (in the fitness model), gender and level of education, we compared dependent tissue shifts with age to those due to V O 2   peak . We found a significant association between cardiorespiratory fitness and brain tissue distribution (white matter, r = 0.30, P = 0.003; grey matter, r = 0.40, P < 0.001) facilitated by direct visualization of the brain tissue shifts due to cardiorespiratory fitness through inverse transformation-a key capability of 3D transport-based morphometry. A strong statistical correlation was found between brain tissue changes related to ageing and those associated with lower cardiorespiratory fitness (white matter, r = 0.62, P < 0.001; grey matter, r = 0.74, P < 0.001). In both cases, frontotemporal regions shifted the most while basal ganglia shifted the least. Our results highlight the importance of cardiorespiratory fitness in maintaining brain health later in life. Furthermore, this work demonstrates 3D transport-based morphometry as a novel neuroinformatic technology that may aid assessment of therapeutic approaches for brain ageing and neurodegenerative diseases.

Effect of dexmedetomidine on perioperative hemodynamics and organ protection in children with congenital heart disease: A randomized controlled trial.

BACKGROUND: This study aimed to investigate the effects of dexmedetomidine (Dex) on hemodynamics and organ protection in congenital heart disease (CHD) children who underwent open-heart surgery under cryogenic cardiopulmonary bypass. METHODS: Ninety children were randomly allocated to group C (0.9% saline 0.2 µg/kg/hour), group D1 (Dex 0.2 µg/kg/hour), and group D2 (Dex 0.4 µg/kg/hour) (n = 30 per group). All participants received fentanyl, propofol and 1% sevoflurane for anesthesia induction. Hemodynamic data were measured from T0 (before the induction) to T7 (30 minutes after extubation). The difference of arterial internal jugular vein bulbar oxygen difference and cerebral oxygen extraction ratio were calculated according to Fick formula. Enzyme-linked immunosorbent assay was performed to detect the serum myocardial, brain and kidney injury markers. The incidence of acute kidney injury (AKI) was calculated by serum creatinine level. Tracheal extubation time, postoperative pain score and emergence agitation score were also recorded. RESULTS: Compared with group C, group D1, and D2 exhibited reduction in hemodynamic parameters, myocardial and brain injury indicators, and tracheal extubation time. There were no significant differences in blood urea nitrogen and neutrophil gelatinase-associated lipocalin or incidence of AKI among the 3 groups. Besides, the incidence of tachycardia, nausea, vomiting and moderate agitation, and the FLACC scale in group D1 and D2 were lower than those in group C. Moreover, Dex 0.4 g/kg/hour could further reduce the dosage of fentanyl and dopamine compared with Dex 0.2 g/kg/hour. CONCLUSIONS: Dex anesthesia can effectively maintain hemodynamic stability and diminish organ injuries in CHD children.

Capsular Polysaccharide From Bacteroides fragilis Protects Against Ulcerative Colitis in an Undegraded Form.

The prominent human symbiont Bacteroides fragilis protects animals from intestinal diseases, such as ulcerative colitis, and its capsular polysaccharide plays a key role in reducing inflammation. B. fragilis strain ZY-312 was isolated from the feces of a healthy breast-fed infant, and the zwitterionic capsular polysaccharide zwitterionic polysaccharide, TP2, was extracted. In rats with 2,4-dinitrobenzenesulfonic acid (DNBS)-induced enteritis, TP2 at an optimal dose of 2.5 mg/kg could significantly alleviate enteritis and reduced the degree of intestinal adhesions, the intestinal ulcer area, and the incidence of ulcers in rats. To understand the underlying mechanism, TP2 was labeled with Fluorescein isothiocyanate and orally administered at a dose of 2.5 mg/kg in rats. TP2 was mainly distributed in the cecum and colorectum, but it was not detected in the blood and other organs except that a compound with a molecular weight greater than that of TP2-FITC was found in liver tissue. During the absorption, distribution, metabolism, and excretion, TP2 was indigestible. These results were further confirmed by investigation in the simulated gastric, intestinal fluid, and colonic fluid with fecal microbiota in vitro, where TP2 remained unaltered at different time points. Furthermore, flora composition was analyzed in simulated colonic fluid with TP2 added and it was found that TP2 increased the abundance of Faecalibacterium, Enterococcus romboutsia, and Ruminococcaceae, whereas the abundance of the phylum Proteobacteria represented by Sutterella, Desulfovibrio, and Enterobacteriaceae was decreased. However, the amount of short-chain fatty acids in the simulated colonic fluid was not changed by intestinal flora post-TP2 addition. In conclusion, these findings confirmed that TP2, a capsular polysaccharide of B. fragilis, protects against ulcerative colitis in an undegraded form.

The association between physical fitness parameters and white matter microstructure in older adults: A diffusion tensor imaging study.

The present study was designed to examine whether different measures of physical fitness are differentially associated with white matter (WM) microstructure in older adults. Fifty-six healthy adults (mean age: 59.14 years) completed a standardized evaluation of physical fitness measurements (e.g., VO2peak , push-ups, abdominal sit-ups, sit-and-reach, t test, and vertical jump). Fractional anisotropy (FA), an index of WM microstructure, was assessed using diffusion tensor imaging. The findings indicated that the cardiorespiratory fitness was positively associated with FA in the right cingulum hippocampus and the left cerebral peduncle. However, other physical fitness metrics were not significantly associated with FA in any region. These results suggest that cardiorespiratory fitness, but not other metrics of fitness, might be sensitive to WM microstructure.

Fast-time consecutive confocal image deblurring using spatiotemporal fused regularization.

Confocal fluorescence microscopy has become a cardinal workhorse instrument in biological research due to its high imaging speed and tissue penetration depth. Unfortunately, the sampled fluorescence signals are intrinsically distorted by optical blurs and photon-counting noise, and the deconvolution method has been introduced to attenuate these degradations. In this paper, we focus mainly on scenarios suffering from severe noise due to low exposure time in a fast-imaging system. To begin with, a Hessian penalty was adopted to depress the artificial staircase effects that were caused by the first-order model (e.g., total variation). Then, to compensate for the weak ability to remove blurring and the produced white-point artifacts of the second-order penalty, we additionally proposed a consistent constraint along the temporal axis based on structural continuity. A remarkable merit of the spatiotemporal fused regularization is retaining the ability of the Hessian matrix to keep details smooth while effectively removing blurring. We employed an alternating-direction-method-of-multipliers algorithm for the corresponding optimization problem. Finally, we conducted experimental comparisons of both the simulated and practical confocal platform, and the excellent performance of the proposed approach reflects the efficiency of the confocal deconvolution work.

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE): Protocol.

Despite the ubiquity of normal age-related cognitive decline there is an absence of effective approaches for improving neurocognitive health. Fortunately, moderate intensity exercise is a promising method for improving brain and cognitive health in late life, but its effectiveness remains a matter of skepticism and debate because of the absence of large, comprehensive, Phase III clinical trials. Here we describe the protocol for such a randomized clinical trial called IGNITE (Investigating Gains in Neurocognition in an Intervention Trial of Exercise), a study capable of more definitively addressing whether exercise influences cognitive and brain health in cognitively normal older adults. We are conducting a 12-month, multi-site, randomized dose-response exercise trial in 639 cognitively normal adults between 65 and 80 years of age. Participants are randomized to (1) a moderate intensity aerobic exercise condition of 150 min/week (N = 213), (2) a moderate intensity aerobic exercise condition at 225 min/week (N = 213), or (3) a light intensity stretching-and-toning control condition for 150 min/week (N = 213). Participants are engaging in 3 days/week of supervised exercise and two more days per week of unsupervised exercise for 12 months. A comprehensive cognitive battery, blood biomarkers and battery of psychosocial questionnaires is assessed at baseline, 6 and 12-months. In addition, brain magnetic resonance imaging, physiological biomarkers, cardiorespiratory fitness, physical function, and positron emission tomography of amyloid deposition are assessed at baseline and at the 12-month follow-up. The results from this trial could transform scientific-based policy and health care recommendations for approaches to improve cognitive function in cognitively normal older adults.

Neuroprotection of reduced thyroid hormone with increased estrogen and progestogen in postpartum depression.

Background: Postpartum depression (PPD) is a common serious mental health problem. Recent studies have demonstrated that hormone therapy serves as a promising therapeutic approach in managing PPD. The present study aims at exploring the role of thyroid hormone (TH), estrogen and progestogen in patients with PPD.Methods: Initially, PPD patients were enrolled and a PPD mouse model was established. The serum levels of estradiol (E2), progesterone (P), triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were subsequently measured. Next, in order to identify the effects of TH, estrogen and progestogen on PPD progression, mice were administrated with E2, P, contraceptives (CA), Euthyrox and methimazole (MMI). Besides, the body weight, activities, basolateral amygdala (BLA) neuron cell structure and the related gene expression of mice were analyzed.Results: The PPD patients and the mice showed elevated serum levels of T3, T4, FT3 and FT4 along with diminished E2, P and TSH levels. In the mice administered with a combination of E2, P, and MMI, decreased TH and increased estrogen and progestogen were detected, which resulted in increased body weight, normal activities, and BLA neuron cell structure. Moreover, brain-derived neurotrophic factor (BDNF) and cAMP-responsive element-binding protein (CREB) were both up-regulated in PPD mice administrated with a combination of E2, P, and MMI, which was accompanied by decreased TH and elevated estrogen and progestogen.Conclusion: Taken together, reduced TH combined with enhanced estrogen and progestogen confers neuroprotection in PPD, highlighting a potential target in prevention and treatment of PPD.

Associations between cardiorespiratory fitness, physical activity, intraindividual variability in behavior, and cingulate cortex in younger adults.

BACKGROUND: Higher levels of cardiorespiratory fitness (CRF) and greater amounts of physical activity have been associated with lower intraindividual variability (IIV) in executive function in children and older adults. In the present study, we examined whether CRF, measured as maximal oxygen uptake (VO2max), and daily volume of moderate-to-vigorous intensity physical activity (MVPA) were associated with IIV of reaction time during performance of the incongruent condition of the Stroop task in younger adults. Further, we examined whether the thickness of the cingulate cortex was associated with regulating variability in reaction time performance in the context of CRF or physical activity. METHODS: CRF (measured as VO2max), accelerometry-measured MVPA, Stroop performance, and thickness of the rostral anterior cingulate cortex (rACC) derived from magnetic resonance imaging data were collected in 48 younger adults (age = 24.58 ± 4.95 years, mean ± SD). Multiple regression was used to test associations between IIV during the Stroop task and CRF, MVPA, and rACC thickness. Mediation was tested using maximum likelihood estimation with bootstrapping. RESULTS: Consistent with our predictions, higher VO2max was associated with greater rACC thickness for the right hemisphere and greater daily amounts of MVPA were associated with greater rACC thickness for both the left and right hemispheres. Greater thickness of the right rACC was associated with lower IIV for the incongruent condition of the Stroop task. CRF and MVPA were not directly associated with IIV. However, we did find that IIV and both CRF and MVPA were indirectly associated via the thickness of the right rACC. CONCLUSION: These results indicate that higher CRF and greater daily volume of MVPA may be associated with lower IIV during the Stroop task via structural integrity of the rACC. Randomized controlled trials of MVPA would provide crucial information about the causal relations between these variables.

Semi-analytical algorithms of ocean color remote sensing under high solar zenith angles.

With the increasing interest in ocean color remote sensing in polar oceans and geostationary ocean color satellite with diurnal observations, it is unavoidable to encounter ocean color retrievals under high solar zenith angles. Under these scenarios, the capability of current remote sensing algorithms is poorly known. In this study, the performance of the two widely used semi-analytical algorithms for the water inherent optical properties (QAA and GSM01) under high solar zenith angle conditions were firstly evaluated based on global in situ data set (SeaBASS-NOMAD). The results showed that the performances of both QAA and GSM01 degraded significantly with the increasing in solar zenith angle (SZA), and the biases increased about 1.3-fold when SZA varied from 30° to 80°. The high uncertainties at high SZA was mainly induced by the systematic overestimation of the key parameter u (ratio of backscattering coefficient to the sum of absorption and backscattering coefficients) at high solar zenith angles. Based on the Hydrolight-simulated data set, a new model (NN-algorithm) for retrieving u from remote sensing reflectance was developed for high solar zenith angle conditions using the neural network method. The validation results revealed that the NN-algorithm could improve the estimation of parameter u and further ocean color products. In addition, our results indicate that a more accurate atmosphere correction is needed to deal with ocean color remote sensing data acquired under large solar zenith angle conditions.

Image deconvolution for confocal laser scanning microscopy using constrained total variation with a gradient field.

As for the confocal laser scanning microscope (CLSM) imaging system, the collected weak fluorescence signals are always distorted by optic blur and severe photon-counting noise, and the deconvolution for CLSM images is a typical ill-posed inverse problem, which is highly sensitive to the measurement noise. To promote the reconstruction quality for characteristics of low intensity and strong noise, we employed the prominent total variation regularization (TV) to enforce the sparsity of a fluorescent image gradient with rich details. However, the well-known reconstruction artifacts (e.g., artificial staircase) emerge with TV prior. To settle this issue, we utilized a robust first-order discretization yielding near-isotropy with a gradient field to depress the reconstruction artifacts. Furthermore, the bound constraint was suited to restrain final reconstruction results from appearing unreasonably explosive. For the proposed optimization minimizer with linear constraint, we take one proximal gradient for approximate estimation of each subproblem under the framework of the inexact alternating direction method of multipliers. Moreover, we incorporated a Nesterov's scheme into the numerical method for acceleration of iteration updating. Compared with other competing methods, both the simulation and practical results demonstrate the effectiveness of our proposed model for CLSM image deconvolution.

Structural brain correlates of fatigue in older adults with and without Parkinson's disease.

Fatigue is one of the most common and disabling nonmotor symptoms seen in Parkinson's disease (PD) and is also commonly seen in healthy older adults. Our understanding of the etiology of fatigue in older adults with or without PD is limited and it remains unclear whether fatigue in PD is specifically related to PD pathology. The objective of this study was thus to determine whether fatigue in PD was associated with structural changes in gray or white matter and explore whether these changes were similar in older adults without PD. Magnetic resonance imaging (T1 weighted) and diffusion tensor imaging were performed in 60 patients with PD (17 females; age = 67.58 ±â€¯5.51; disease duration = 5.67 ±â€¯5.83 years) and 41 age- and sex- matched healthy controls. FSL image processing was used to measure gray matter volume, fractional anisotropy, and leukoariosis differences. Voxel-based morphometry confirmed gray matter loss across the dorsal striatum and insula in the PD patient cohort. PD patients with fatigue had reduced gray matter volume in dorsal striatum relative to PD patients without fatigue (P < 0.05 False Discovery Rate corrected). No significant fatigue-related structural atrophy was found in controls. There were no areas of significant fractional anisotropy differences between high and low fatigue subjects in either the PD or non-PD groups. Control participants with high fatigue, but not PD, showed significantly greater total leukoariosis volumes (p = 0.03). Fatigue in PD is associated with unique structural changes in the caudate and putamen suggesting fatigue in PD is primarily related to PD pathology, particularly in the dorsal striatum, and not simply a consequence of aging.