1.
Org Biomol Chem
; 20(18): 3755-3762, 2022 05 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35420116
RESUMO
A highly regio- and chemoselective synthesis of 1H-isoindoliums through a facile and novel cascade cyclization reaction of propargylamine-based 1,6-diynes under mild conditions has been developed. Different functional groups were compatible under the optimized reaction conditions, giving the corresponding products in up to 94% yields. Upon treatment with a base, the alkyne moiety of 1H-isoindoliums could be further transformed to allenes in excellent yields.