Blood metabolites mediate the causal relationship between circulating CX3CL1 levels and prostate cancer: A 2-step Mendelian randomization study.

Chemokines influence the progression of prostate cancer (PCa) through multiple mechanisms. However, the effect of C-X3-C chemokine ligand 1 (CX3CL1) on PCa risk remains controversial. Our study aimed to investigate whether circulating CX3CL1 is causally associated with PCa and to identify metabolites that have mediating effects using the 2-step bidirectional Mendelian randomization (MR) analysis process. Inverse variance weighting (IVW) results were used as the primary observations, while additional sensitivity analyses were conducted. For each standard deviation increase exhibited by the circulating CX3CL1 levels, the risk of PCa was reduced by 0.4% (IVW: OR = 0.996, [95% CI = 0.994-0.998], P < .001), and blood alliin levels increased by 19% (IVW: OR = 1.185, [95% CI = 1.01-1.54], P = .003). For each standard deviation increase in the blood alliin levels, the risk of PCa was reduced by 0.1% (IVW: OR = 0.999, [95% CI = 0.997-0.999], P = .03). Therefore, the protective effect of circulating CX3CL1 on PCa may be mediated by blood alliin levels (mediated proportion = 6.7%). The results supported the notion that high levels of circulating CX3CL1 indicate a lower PCa risk and the idea that the food-derived antioxidant alliin may mediate this association. We emphasize that the use of CX3CL1 as a protective factor against PCa may provide new strategies for PCa prevention and care in the future.

Cryptanalysis and Improvement of Several Identity-Based Authenticated and Pairing-Free Key Agreement Protocols for IoT Applications.

Internet of Things (IoT) applications have been increasingly developed. Authenticated key agreement (AKA) plays an essential role in secure communication in IoT applications. Without the PKI certificate and high time-complexity bilinear pairing operations, identity-based AKA (ID-AKA) protocols without pairings are more suitable for protecting the keys in IoT applications. In recent years, many pairing-free ID-AKA protocols have been proposed. Moreover, these protocols have some security flaws or relatively extensive computation and communication efficiency. Focusing on these problems, the security analyses of some recently proposed protocols have been provided first. We then proposed a family of eCK secure ID-AKA protocols without pairings to solve these security problems, which can be applied in IoT applications to guarantee communication security. Meanwhile, the security proofs of these proposed ID-AKA protocols are provided, which show they can hold provable eCK security. Some more efficient instantiations have been provided, which show the efficient performance of these proposed ID-AKA protocols. Moreover, comparisons with similar schemes have shown that these protocols have the least computation and communication efficiency at the same time.

Integer particle swarm optimization based task scheduling for device-edge-cloud cooperative computing to improve SLA satisfaction.

Task scheduling helps to improve the resource efficiency and the user satisfaction for Device-Edge-Cloud Cooperative Computing (DE3C), by properly mapping requested tasks to hybrid device-edge-cloud resources. In this paper, we focused on the task scheduling problem for optimizing the Service-Level Agreement (SLA) satisfaction and the resource efficiency in DE3C environments. Existing works only focused on one or two of three sub-problems (offloading decision, task assignment and task ordering), leading to a sub-optimal solution. To address this issue, we first formulated the problem as a binary nonlinear programming, and proposed an integer particle swarm optimization method (IPSO) to solve the problem in a reasonable time. With integer coding of task assignment to computing cores, our proposed method exploited IPSO to jointly solve the problems of offloading decision and task assignment, and integrated earliest deadline first scheme into the IPSO to solve the task ordering problem for each core. Extensive experimental results showed that our method achieved upto 953% and 964% better performance than that of several classical and state-of-the-art task scheduling methods in SLA satisfaction and resource efficiency, respectively.

Survival benefit of platinum-based regimen in early stage triple negative breast cancer: A meta-analysis of randomized controlled trials.

Platinum (Pt)-based chemo-regimens have been proved effective in neoadjuvant and salvage chemotherapy of triple negative breast cancer (TNBC). However, the survival benefit of Pt-based regimens in early stage TNBC(eTNBC) treatment has remained unclear. We conducted a meta-analysis to explore its role in improving the clinical outcomes of eTNBC. We carried out a comprehensive literature search on 15 March 2021 for randomized controlled trials (RCTs) comparing ajuvant/neoadjuvant Pt-based and Pt-free chemo-regimens in eTNBC patients, according to PRISMA 2020. We extracted the survival data and utilized the STATA software to calculate the summarized hazard ratios (HRs) and 95% confidence interval (95% CI) for overall survival (OS) and disease-free survival (DFS). Seven eligible RCTs enrolling a total of 2,027 eTNBC patients were identified in this meta-analysis, with 1,007 receiving Pt-free regimens, and the other 1,020 patients receiving Pt-based regimens, respectively. Patients in Pt-based regimens arm were associated with significant improved DFS (HR = 0.70, 95% CI: 0.58-0.84), and OS (HR = 0.78, 95% CI: 0.61-1.00). The survival benefits of DFS remained consistent in both the two strategies of Pt usage, either adding Pt to standard anthracyclines&taxanes based regimens (A&T + Pt), or combination of Pt and taxanes alone (TPt). The survival benefits also remained consistent in either neoadjuvant or adjuvant use of Pt. The present meta-analysis of RCTs revealed that Pt-based chemo-regimens could significantly improve both DFS and OS for eTNBC patients. Based on efficiency and toxicity, we recommend Pt-based regimens for eTNBC, especially the "A&T + Pt" mode if the toxicities are tolerable, which may lead TNBC therapy into a new era.

An integrated guidance and control approach in three-dimensional space for hypersonic missile constrained by impact angles.

A new robust three-dimensional integrated guidance and control (3D-IGC) approach is investigated for sliding-to-turn (STT) hypersonic missile, which encounters high uncertainties and strict impact angle constraints. First, a nonlinear state-space model with more generality is established facing to the design of 3D-IGC law. With regard to the as-built nonlinear system, a robust dynamic inversion control (RDIC) approach is proposed to overcome the robustness deficiency of traditional DIC, and then it is applied to construct the basic 3D-IGC law combining with backstepping method. In order to avoid the problems of "explosion of terms" and high-frequency chattering, an improved 3D-IGC law is further proposed by introducing dynamic surface control and continuous approximation approaches. From the computer simulation on a hypersonic missile, the proposed 3D-IGC law not only guarantees the stable flight, but also presents the precise control on terminal locations and impact angles. Moreover, it possesses smooth control output and strong robustness.