RESUMO
Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a CC bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.
Assuntos
Anti-Inflamatórios/farmacologia , Antivirais/farmacologia , Frutas/química , Herpesvirus Humano 1/efeitos dos fármacos , Schisandra/química , Sesquiterpenos/farmacologia , Anti-Inflamatórios/química , Anti-Inflamatórios/isolamento & purificação , Antivirais/química , Antivirais/isolamento & purificação , Herpes Simples/tratamento farmacológico , Humanos , Modelos Moleculares , Neutrófilos/efeitos dos fármacos , Neutrófilos/imunologia , Sesquiterpenos/química , Sesquiterpenos/isolamento & purificaçãoRESUMO
Phytochemical investigation of the ethanol extract from the fruits of Schisandra sphenanthera has resulted in isolation of seven new oxygenated lignans (1-7), in addition to 11 known compounds (8-18). Their structures were determined on the basis of 2D-NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated components were evaluated with a reporter gene assay that measures their anti-liver fibrosis activity. Compounds 1, 2, 4, 11, 13, 14 and 18 exhibited significant anti-inflammatory activity on HSC-T6 test.