In situ Light-Writable Orientation Control in Liquid Crystal Elastomer Film Enabled by Chalcones.

Liquid crystal elastomers (LCEs) are stimulus-responsive materials with intrinsic anisotropy. However, it is still challenging to in situ program the mesogen alignment to realize three-dimensional (3D) deformations with high-resolution patterned structures. This work presents a feasible strategy to program the anisotropy of LCEs by using chalcone mesogens that can undergo a photoinduced cycloaddition reaction under linear polarized light. It is shown that by controlling the polarization director and the irradiation region, patterned alignment distribution in a freestanding LCE film can be created, which leads to complex and reversible 3D shape-morphing behaviors. The work demonstrates an in situ light-writing method to achieve sophisticated topography changes in LCEs, which has potential applications in encryption, sensors, and beyond.

Photocontrollable Elongation Actuation of Liquid Crystal Elastomer Films with Well-Defined Crease Structures.

Although liquid crystal elastomers (LCEs) have demonstrated various applications in artificial muscles and soft robotics, their inherent flexibility and orientation-dependent forces limit their functions. For instance, LCEs can sustain a high actuation force when they contract but cannot elongate to drive loads with large displacements. In this study, it is demonstrated that photocontrollable elongation actuation with a large strain can be achieved in polydomain LCEs by programming the crease structures in a well-defined order to couple the actuation forces. Efficient photoactuation without overheating-induced damage to the materials is favored, based on the well-designed photosensitive molecular switch crosslinker via the synergy of photochemical and photothermal effects. The LCE actuator can jack up heavy loads, elongate freely, and contract back to manipulate distant objects. Theoretical analysis based on a finite element simulation of the deformation energy during the actuation process reveals a trade-off between the abilities of jacking-up and withstanding load. More importantly, this study simplifies the design of a single material with functions inherent only in other soft robotic devices based on the assembly of multiple modules, thus providing a design strategy for surpassing instinctive properties of conventional soft materials to expand the functions of soft robotics.

Mechanochromic Polymers Based on Mechanophores.

In recent years, diverse stimuli-responsive allochroic materials have rapidly been developed, and smart materials with mechanochromic properties in particular have received increasing attention. This is because force fields have the advantage of being large and controllable compared to other stimulation modalities. Mechanochromic polymers mainly convert mechanical force signals into optical signals, which makes them suitable for applications in bionic actuators, encryption, and signal sensing. In this review, we summarize recent research progress in the design and development of mechanochromic polymers that are classified into two categories. The first category comprises those based on mechanophores that are physically dispersed in polymer matrices in the form of supramolecular aggregates. The second category comprises those based on mechanophores that are covalently linked to polymer networks. We focus on the working mechanisms of the mechanophores and their potential applications, which include damage monitoring and signal sensing.

Thermo- and Mechanochromic Camouflage and Self-Healing in Biomimetic Soft Actuators Based on Liquid Crystal Elastomers.

In nature, many mysterious creatures capable of deformation camouflage, color camouflage, and self-healing have inspired scientists to develop various biomimetic soft robots. However, the systematic integration of all the above functionalities into a single soft actuator system still remains a challenge. Here we chemically introduce a multi-stimuli-responsive tetraarylsuccinonitrile (TASN) chromophore into a liquid crystal elastomer (LCE) network through a facile thiol-ene photoaddition method. The obtained TASN-LCE soft actuators not only exhibit reversible shape-morphing and reversible color-changing behavior in response to heat and mechanical compression, but also show excellent self-healing, reprogramming and recycling characteristics. We hope that such a TASN-LCE actuator system endowed with dynamic distortion, thermo- and mechano-chromic camouflage, and self-healing functionalities would pave the way for further development of multifunctional biomimetic soft robotic devices.

Accurate Monitoring and Multiple Evaluations of Mitophagy by a Versatile Two-Photon Fluorescent Probe.

Mitophagy plays a critical role in regulating and maintaining cellular functions, particularly regulating the quantity and quality of mitochondria. In this research, a multifunctional two-photon fluorescent probe Mito-PV with improved mitochondria-anchored ability was designed. The proposed probe can track the fluctuation of polarity and viscosity in mitochondria simultaneously with two well-distinguished emissions. It can also precisely visualize the change in mitochondrial morphology (including mitochondrial form factor and length). The real-time and accurate monitoring of mitophagy under two-photon excitation was successfully achieved by utilizing probe Mito-PV through supervising the alterations of diverse mitophagy-related parameters (including colocalization coefficient, polarity, viscosity, and mitochondrial morphology). In addition, probe Mito-PV can be applied to evaluate drug bpV(phen) as an effective mitophagy inhibitor. Therefore, our work may provide a more efficient and reliable method for precisely monitoring mitophagy from multiple evaluations.

Healable and Rearrangeable Networks of Liquid Crystal Elastomers Enabled by Diselenide Bonds.

Based on liquid crystal elastomer (LCE) materials, hierarchically structured soft actuators can meet some requirements for "human-friendly" working mode and execute complex tasks with intelligent adaptation to environmental changes. However, few researchers have paid much attention to the preparation methods of multicomponent/hierarchical LCE actuators. In this communication, we demonstrate the successful integration of an exchangeable diselenide chain extender for the preparation of dynamic LCEs, which could be reprogrammed on heating or under visible light illumination. Moreover, the rearrangeable polydiselenide networks could be applied to develop the self-welding technology toward fabricating hierarchically structured LCE actuators with sophisticated deformability without using any auxiliary reagent (adhesive, tape, catalysts or initiator) during the assembling process.

Bioinspired Synergistic Photochromic Luminescence and Programmable Liquid Crystal Actuators.

Bioinspired smart materials with synergistic allochroic luminescence and complex deformation are expected to play an important role in many areas of science and technology. However, it is still challenging to fabricate such soft actuators with high programmability that can be manipulated in situ with high spatial resolution. Herein, we have incorporated terminally functionalized aggregation-induced emission active tetraphenylethene derivative and photochromic spiropyran moieties into the networks of liquid crystal elastomers through covalent bonding to obtain the synergistic photochromic luminescence and programmable soft actuators. Bio-mimic functions and light-induced auxetic metamaterial-like devices were shown to be feasible based on the combination of assembly and origami-programming strategy. These bioinspired devices with synergistic photochromic luminescence and complex photodeformation abilities provide an elegant strategy to design multi-functional liquid crystal actuators.

Rational design of a ratiometric two-photon fluorescent probe for real-time visualization of apoptosis.

A dialdehyde-functionalized ratiometric two-photon fluorescent probe (Mito-DCHO) based on a symmetric carbazole-containing two-dimensional ICT system was rationally designed for cysteine-specific detection in mitochondria, which was utilized for real-time assessing and dual-channel visualization of the early stage of apoptosis by monitoring mitochondrial oxidative stress levels.

Design of a two-photon fluorescent probe for selective recognition of Au(III) over Au(I) and its application of imaging in vitro and in vivo.

A highly selective two-photon fluorescent probe (PyCM-1) for Au3+ was developed with distinct "turn on" fluorescence response, low detection limit (22nM) and large two-photon absorption cross-sections (696 GM at 860nm). Its high selectivity for Au3+ over Au+ was achieved via the modification on the type of coordination atoms in the Schiff base receptor. Co-staining experiments showed that the probe PyCM-1 could co-localize specifically with mitochondria. Moreover, the two-photon confocal fluorescence imaging results demonstrated the probe's capability for visualizing Au3+in vitro and in vivo.