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J Agric Food Chem ; 58(24): 12729-34, 2010 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-21121609

RESUMO

To investigate the effects of whey protein concentrate (WPC) on antioxidant statuses and the lymphocyte subpopulations in the rats with alcohol intake, the antioxidant statuses in the peripheral blood (PB) and the lymphocyte subpopulations in the PB, spleen, and bone marrow (BM) of the rats fed with WPC (0.334 g/kg) and alcohol (6 g/kg) for 3 months were analyzed. Results showed that the effects of WPC on the glutathione peroxidase and glutathione in the PB, the T and B cells in the spleen, and the B cells in the BM were more apparent in the rats with alcohol intake; however, they are not apparent in the controls. Taken together, our results indicated that the immunity of rats might be enhanced by the increased antioxidant ability after WPC supplementation and the effects of WPC on the lymphocyte subpopulations were mainly in the spleen and BM and not in the PB.


Assuntos
Consumo de Bebidas Alcoólicas/tratamento farmacológico , Consumo de Bebidas Alcoólicas/imunologia , Subpopulações de Linfócitos/efeitos dos fármacos , Proteínas do Leite/administração & dosagem , Consumo de Bebidas Alcoólicas/efeitos adversos , Animais , Antioxidantes/administração & dosagem , Glutationa/imunologia , Glutationa Peroxidase/imunologia , Humanos , Subpopulações de Linfócitos/enzimologia , Subpopulações de Linfócitos/imunologia , Masculino , Modelos Animais , Ratos , Ratos Sprague-Dawley , Proteínas do Soro do Leite
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