RESUMO
OBJECTIVE: To examine the relationship between preoperative biliary drainage and the morbidity and mortality associated with pancreaticoduodenectomy. SUMMARY BACKGROUND DATA: Recent reports have suggested that preoperative biliary drainage increases the perioperative morbidity and mortality rates of pancreaticoduodenectomy. METHODS: Peri-operative morbidity and mortality were evaluated in 300 consecutive patients who underwent pancreaticoduodenectomy. Univariate and multivariate logistic regression analyses were done to evaluate the relationship between preoperative biliary decompression and the following end points: any complication, any major complication, infectious complications, intraabdominal abscess, pancreaticojejunal anastomotic leak, wound infection, and postoperative death. RESULTS: Preoperative prosthetic biliary drainage was performed in 172 patients (57%) (stent group), 35 patients (12%) underwent surgical biliary bypass performed during prereferral laparotomy, and the remaining 93 patients (31%) (no-stent group) did not undergo any form of preoperative biliary decompression. The overall surgical death rate was 1% (four patients); the number of deaths was too small for multivariate analysis. By multivariate logistic regression, no differences were found between the stent and no-stent groups in the incidence of all complications, major complications, infectious complications, intraabdominal abscess, or pancreaticojejunal anastomotic leak. Wound infections were more common in the stent group than the no-stent group. CONCLUSIONS: Preoperative biliary decompression increases the risk for postoperative wound infections after pancreaticoduodenectomy. However, there was no increase in the risk of major postoperative complications or death associated with preoperative stent placement. Patients with extrahepatic biliary obstruction do not necessarily require immediate laparotomy to undergo pancreaticoduodenectomy with acceptable morbidity and mortality rates; such patients can be treated by endoscopic biliary drainage without concern for increased major complications and death associated with subsequent pancreaticoduodenectomy.
Assuntos
Drenagem , Neoplasias Pancreáticas/cirurgia , Pancreaticoduodenectomia/efeitos adversos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Cuidados Pré-OperatóriosRESUMO
PURPOSE: A recent multicenter study of preoperative chemoradiation and pancreaticoduodenectomy for localized pancreatic adenocarcinoma suggested that biliary stent-related complications are frequent and severe and may prevent the delivery of all components of multimodality therapy in many patients. The present study was designed to evaluate the rates of hepatic toxicity and biliary stent-related complications and to evaluate the impact of this morbidity on the delivery of preoperative chemoradiation for pancreatic cancer at a tertiary care cancer center. PATIENTS AND METHODS: Preoperative chemoradiation was used in 154 patients with resectable pancreatic adenocarcinoma (142 patients, 92%) or other periampullary tumors (12 patients, 8%). Patients were treated with preoperative fluorouracil (115 patients), paclitaxel (37 patients), or gemcitabine (two patients) plus concurrent rapid-fractionation (30 Gy; 123 patients) or standard-fractionation (50.4 Gy; 31 patients) radiation therapy. The incidences of hepatic toxicity and biliary stent-related complications were evaluated during chemoradiation and the immediate 3- to 4-week postchemoradiation preoperative period. RESULTS: Nonoperative biliary decompression was performed in 101 (66%) of 154 patients (endobiliary stent placement in 77 patients and percutaneous transhepatic catheter placement in 24 patients). Stent-related complications (occlusion or migration) occurred in 15 patients. Inpatient hospitalization for antibiotics and stent exchange was necessary in seven of 15 patients (median hospital stay, 3 days). No patient experienced uncontrolled biliary sepsis, hepatic abscess, or stent-related death. CONCLUSION: Preoperative chemoradiation for pancreatic cancer is associated with low rates of hepatic toxicity and biliary stent-related complications. The need for biliary decompression is not a clinically significant concern in the delivery of preoperative therapy to patients with localized pancreatic cancer.
Assuntos
Adenocarcinoma/cirurgia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ductos Biliares/patologia , Terapia Neoadjuvante , Neoplasias Pancreáticas/cirurgia , Pancreaticoduodenectomia , Stents/efeitos adversos , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/radioterapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Ampola Hepatopancreática , Antimetabólitos Antineoplásicos/administração & dosagem , Antineoplásicos Fitogênicos/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Neoplasias do Ducto Colédoco/tratamento farmacológico , Neoplasias do Ducto Colédoco/radioterapia , Neoplasias do Ducto Colédoco/cirurgia , Desoxicitidina/administração & dosagem , Desoxicitidina/análogos & derivados , Feminino , Fluoruracila/administração & dosagem , Seguimentos , Hospitalização , Humanos , Incidência , Fígado/efeitos dos fármacos , Fígado/efeitos da radiação , Masculino , Pessoa de Meia-Idade , Paclitaxel/administração & dosagem , Neoplasias Pancreáticas/tratamento farmacológico , Neoplasias Pancreáticas/radioterapia , Dosagem Radioterapêutica , Estudos Retrospectivos , GencitabinaRESUMO
The inherent weakness of repairing the surgically divided respiratory diaphragm is that it is a muscle to muscle closure which can easily tear. During the thoracoabdominal exposure of the thoracolumbar vertebrae, the left hemidiaphragm is divided circumferentially. Possible due to unique conditions related to these operations the diaphragm could not initially be reapproximated primarily in about 20% of the patients. A modified Rumel technique is described as an aid for closing these difficult divided diaphragms. This simple techniques succeeds by distributing the wound tension along the entire diaphragmatic suture line and not on one suture especially while being tied.
Assuntos
Diafragma/cirurgia , Vértebras Lombares/cirurgia , Técnicas de Sutura , Vértebras Torácicas/cirurgia , HumanosRESUMO
Interest appears to be increasing in the anterior approach for the surgical management of thoracic and lumbar vertebral fractures. However, adequate exposure requires a self-retaining retractor system. Current stainless steel systems, by interfering with fluoroscopic visualization of bony fractures and landmarks, require frequent repositioning. We found that a newly available aluminum alloy retractor system provides excellent operative exposure without significant fluoroscopic obstruction. This system eliminates the frustration of frequent retractor repositioning and saves us an average of 20 to 30 minutes of operating room time per vertebral repair.
Assuntos
Dissecação/instrumentação , Vértebras Lombares/lesões , Fraturas da Coluna Vertebral/cirurgia , Instrumentos Cirúrgicos/normas , Vértebras Torácicas/lesões , Alumínio , Desenho de Equipamento , Fluoroscopia , Humanos , Postura , Fraturas da Coluna Vertebral/diagnóstico por imagem , Fatores de TempoRESUMO
With most combined kidney and pancreas transplants the transplant pancreatic exocrine secretions are managed with urinary bladder drainage. Because of the associated metabolic and infectious complications, many pancreatic transplants require later conversion to enteric drainage, and the trend in this country is now toward primary enteric drainage. Unlike with urinary bladder drainage when direct cystoscopy can be performed, a disadvantage with enteric drainage is that problems such as bleeding from a transplanted pancreas and attached duodenal segment are not easily evaluated. A case of a cytomegalovirus-related bleeding ulcer in an enteric drained pancreas is presented, along with a review of the possible diagnostic evaluation.
Assuntos
Drenagem/efeitos adversos , Hemorragia Gastrointestinal/etiologia , Transplante de Pâncreas/efeitos adversos , Hemorragia Pós-Operatória/etiologia , Adulto , Cadáver , Terapia Combinada , Infecções por Citomegalovirus/diagnóstico , Infecções por Citomegalovirus/etiologia , Infecções por Citomegalovirus/terapia , Drenagem/métodos , Feminino , Hemorragia Gastrointestinal/diagnóstico , Hemorragia Gastrointestinal/terapia , Humanos , Intestinos , Transplante de Rim/efeitos adversos , Transplante de Rim/métodos , Transplante de Pâncreas/métodos , Hemorragia Pós-Operatória/diagnóstico , Hemorragia Pós-Operatória/terapiaRESUMO
A debate has raged in the surgical literature about the use of a running suture verses interrupted sutures for abdominal wound closures. For most abdominal wounds either method can probably be used safely. A modified interrupted technique is described which may be useful for some difficult wounds. One of the main advantages of this technique is that the wound tension is equally distributed along the entire wound and not only on the last placed suture. The sutures are easily tied without having "to fight the wound".
Assuntos
Músculos Abdominais/cirurgia , Técnicas de Sutura , Humanos , SuturasRESUMO
General surgeons often provide the exposure for the anterior repair of vertebral body lesions. The standard anterior approach to the thoracolumbar junction (T11-L1) is a transpleural 9th or 10th rib thoracoabdominal incision. From October 1995 through March 1997, 22 patients underwent anterior repair of thoracolumbar junction vertebral lesions through an alternative 11th rib resection while maintaining an extrapleural approach. Exposure was excellent, as judged by the neurosurgical team completing the repairs. Chest tubes were not used routinely, and all patients healed without complications. A major limitation of the 11th rib extrapleural approach to the thoracolumbar junction has been poor exposure. This problem is eliminated with the use of an abdominal self-retaining retractor system. With many potential advantages to this 11th rib exposure (less pain, fewer pulmonary problems, and better wound healing), we consider the 11th rib incision to be the approach of choice to the thoracolumbar junction and recommend renewed interest in this incision.
Assuntos
Vértebras Lombares/cirurgia , Postura , Costelas/cirurgia , Vértebras Torácicas/cirurgia , Toracotomia/métodos , Seguimentos , Humanos , Dor Pós-Operatória/prevenção & controle , Doenças da Coluna Vertebral/cirurgia , Toracotomia/efeitos adversos , Toracotomia/instrumentação , Resultado do Tratamento , CicatrizaçãoRESUMO
Radiographically detectable gas only occasionally fills the lumen of the vermiform appendix (pneumoappendix), and the diagnostic significance of this gas remains unresolved in the radiologic literature. The following case report is a previously unreported finding of a postoperative plain abdominal radiograph showing a dilated pneumoappendix after an inversion-ligation appendectomy. A brief review of the surgical technique is included to help explain these radiographic findings.
Assuntos
Apendicectomia/métodos , Enfisema/diagnóstico por imagem , Complicações Pós-Operatórias , Adulto , Feminino , Humanos , Transplante de Rim , Transplante de Pâncreas , RadiografiaRESUMO
With trauma being common in this country and over 110,000 recent organ transplants performed, transplant recipients may become trauma victims. At present, only a few older small series of traumatized transplant patients exist. At the University of Arkansas, over the past 40 months, 12 patients with significant trauma were retrospectively identified (seven with kidney and five with combined kidney and pancreas transplants). The most common causes of trauma were car accidents and falls. All patients suffered closed skeletal fractures, and no transplanted organs were directly injured or lost. Complications included death, deep vein thrombosis, renal failure, sepsis, and pneumonia. In spite of immunosuppression and preexisting renal osteodystrophy, fractures in the surviving patients healed, with a mean follow-up of 15 months. A large series of traumatized transplant patients is presented with a review of the management of traumatic injuries for each type of organ transplant. A trauma transplant registry is needed to formulate appropriate management and follow-up.
Assuntos
Transplante de Órgãos , Complicações Pós-Operatórias/terapia , Ferimentos e Lesões/terapia , Adolescente , Adulto , Idoso , Feminino , Humanos , Imunossupressores/uso terapêutico , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Resultado do Tratamento , Ferimentos e Lesões/complicações , Ferimentos e Lesões/diagnóstico , Ferimentos e Lesões/etiologiaRESUMO
For combined kidney and pancreas transplant recipients infectious complications remain a major source of morbidity. With as many antibiotic protocols as transplant centers, the exact type and duration for prophylactic wound antibiotics remains undefined. A retrospective review of our series of 40 combined kidney and pancreas transplants was performed using a single 1 g dose of cefazolin preoperatively along with cefazolin bladder and intra-abdominal irrigation. Two patients developed superficial wound infections for a rate of 5% (2/37). The deep wound infection rate was 11% (4/37), and all followed either a bladder anastomotic leak or the initial development of transplant pancreatitis. Our overall rate of 16% is very comparable with other series of combined kidney and pancreas transplant recipients. To help eliminate the potential development of superinfections and resistant organisms, a single dose of antibiotics appears to be as effective for wound prophylaxis in these patients when compared to multiple-antibiotic and multiple-day regiments. A randomized prospective study of prophylactic antibiotics in combined kidney and pancreas transplants is needed.