Los Angeles County-University of Southern California Medical Center clinical pathology case conference: extreme hypermagnesemia in a neonate.

A preterm male infant born at 33 weeks of gestation developed respiratory depression and apnea at approximately 20 h after birth. Laboratory tests indicated severe hypermagnesemia, acidosis, and hypercalcemia. Cord blood and maternal blood concentrations of magnesium were normal. The effects and possible causes of hypermagnesemia are reviewed. The infant recovered with treatment, although the etiology of his hypermagnesemia remains unknown.

Discoid lupus erythematosus of the eyelids.

Discoid lupus erythematosus (DLE) is a chronic skin disease that may affect the eyelids. Unless suspected, these lid lesions may resemble chronic blepharitis and persist for years. We present the clinicopathologic features of DLE from the lids of seven patients, electron microscopic features of one case, and a review of 31 previously reported cases.

Brain damage among mentally disordered sex offenders.

The incidence and nature of structural brain dysfunction was investigated in a pilot study sample of individuals currently assigned the Nebraska Penal Code designation of mentally disordered sexual offender. It was hypothesized that the sexual offenders would show a significantly higher incidence of dysfunction than a psychosocially normal group as evidenced by computed tomography scan measures, regional cerebral blood flow, and neuropsychological instruments. The hypothesis was tested by two different methods. One method used a 160 by 160 printout of density numbers generated by computer from computed tomography scans administered to the sexual offenders. The second method used mean blood flow data generated from a Harshaw TASC-5 Regional Cerebral Blood Flow analysis system. Additionally, the Luria-Nebraska Neuropsychological Test Battery was administered as a measure of the behavioral correlates of brain dysfunction. Preliminary analyses indicate that 50% of the sexual offenders tested showed brain dysfunction as demonstrated by decreased density measures, decreased blood flow, and performance deficits on the Luria Battery. The implications of these findings, if confirmed, are substantial on issues of criminal responsibility, sentencing, treatment, and rehabilitation of the sex offender. Case reports of the patients studied are presented.

Time factors and orgasmic response.

A retrospective review of data from a 619-member female sample presenting for treatment of sexual dysfunction was conducted to determine if foreplay and intromission duration variables were related to sexual dysfunction. Patients were assigned to coitally anorgasmic and noncoitally anorgasmic, coitally anorgasmic and noncoitally orgasmic, or coitally and noncoitally orgasmic categories on the basis of interview data collected by a nurse-physician team. Duration measure differences are not found between diagnostic categories. However, significant differences are reported for the duration measures between status of relationship groupings: married, single, divorced, or cohabitating (p less than 0.05). Data from the sexually dysfunctional sample are compared with data from the surveys of Kinsey, Fisher, and Hunt. The importance of extended foreplay and intromission in enhancing female coital orgasmic response is not supported.