1.
Immune response to two different dosing schedules of the anthrax vaccine precipitated (AVP) vaccine.
Vaccine
; 25(32): 6089-97, 2007 Aug 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17604880
RESUMO
A pilot study compared the immune response of regular (0, 3, 6, 32 weeks) and extended (0, 10, 13, 32 weeks) schedules of the UK anthrax vaccine (anthrax vaccine precipitated, AVP). Concentrations of antibodies to protective antigen (PA) were higher (p<0.05) among recipients of the extended (n=7) versus regular schedule (n=6) at week 32, and 2 weeks after the second and third vaccinations. Toxin neutralisation assay levels and anti-lethal factor antibodies followed patterns similar to anti-PA antibodies. Extending the interval between the first two AVP vaccinations may produce a stronger immune response, but persistence of this effect needs further study.
Assuntos
Vacinas contra Antraz/administração & dosagem , Vacinas contra Antraz/imunologia , Antraz/imunologia , Adulto , Anticorpos Antibacterianos/sangue , Precipitação Química , Relação Dose-Resposta Imunológica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes de Neutralização
2.
Occup Environ Med
; 64(7): 490-1, 2007 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17582088