RESUMO
Objective:To investigate the effects of CPAP for obstructive sleep apneaï¼OSAï¼ combined CHDï¼coronary heart diseaseï¼ long-term prognosis. Method:One hundred and twenty cases of OSA combind CHD in gansu province people's hospital sleep center were randomly divided into two groups according to apnea hypopnea indexï¼AHIï¼, group Aï¼light, medium OSA and CHDï¼ 60 cases, group Bï¼severe OSA and CHDï¼ 60 cases. Contrast analysis and comparison between two groups PSGï¼Polysomnographyï¼ parameters, and the differences between the degree of coronary artery lesions and CPAP therapy effect on coronary long-term prognosis. Result:Compared group B with A, AHI, BMI, LSaOî2, Epworth sleepiness scaleï¼ESSï¼ score, the amino acid homocysteine, the prevalence of hypertension, type 2 diabetes, the prevalence of acute myocardial infarctionï¼amiï¼ and vascular lesions and SYNTAX score increased significantlyï¼P<0.05ï¼. The ejection fraction decreased significantlyï¼P<0.05ï¼. The BNPï¼Brain natriuretic peptideï¼ and cTNTï¼cardiac troponin, cTnï¼ concentration there was no significant difference between the two groupsï¼P>0.05ï¼. CPAP treatmentï¼30.0±4.2ï¼ months later, Group B: CAPA + conventional treatment group, compared with the simple routine LSaOî2, ejection fraction increased significantlyï¼P<0.05ï¼, AHI, cardiovascular adverse events, vascular lesions, SYNTAX score, the BNP and TNT concentration significantly reducedï¼P<0.05ï¼; Group A: AHI, decreased significantlyï¼P<0.05ï¼, LSaOî2increased significantlyï¼P<0.05ï¼, ejection fraction, cardiovascular adverse events, vascular lesions, SYNTAX score, there was no significant difference between the BNP and TNT concentration; Survival analysis showed that: Group A CPAP+conventional treatment group cumulative survival rate higher than the conventional treatment group, but there was no statistically significant differenceï¼P=0.260ï¼. Group B: CPAP+conventional treatment group total survival rate was significantly higher than that of the conventional treatment groupï¼P<0.001ï¼; Conclusion:With the increase of the severity of OSA, OSA merge CHD coronary artery pathological changes degree aggravating, CPAP therapeutic benefit the long-term prognosis of CHD.
