Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 9 de 9
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Nat Neurosci ; 26(4): 537-541, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36894655

RESUMO

The structure of the human connectome develops from childhood throughout adolescence to middle age, but how these structural changes affect the speed of neuronal signaling is not well described. In 74 subjects, we measured the latency of cortico-cortical evoked responses across association and U-fibers and calculated their corresponding transmission speeds. Decreases in conduction delays until at least 30 years show that the speed of neuronal communication develops well into adulthood.


Assuntos
Conectoma , Substância Branca , Pessoa de Meia-Idade , Adolescente , Humanos , Criança , Encéfalo/fisiologia , Neurônios , Transdução de Sinais
2.
Clin Neurophysiol ; 133: 126-134, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34844043

RESUMO

OBJECTIVE: We retrospectively assessed the localizing value of patient-history-based semiology (PHS), video-based semiology (VS), long-term monitoring video electroencephalography (LTM-VEEG) and interictal high resolution electric source imaging (HR-ESI) in the presurgical workup of patients with tuberous sclerosis complex (TSC). METHODS: Data from 24 consecutive TSC surgical candidates who underwent both HR-ESI and LTM-VEEG was retrospectively collected. PHS and VS were analyzed to hypothesize the symptomatogenic zone localization. LTM-VEEG and HR-ESI localization results were extracted from the diagnostic reports. Localizing value was compared between modalities, taken the resected/disconnected area of surgical patients in consideration. HR-ESI's impact on the epileptogenic zone hypothesis and surgical workup was evaluated. RESULTS: Semiology, interictal EEG, ictal EEG and HR-ESI were localizing in 25%, 54%, 63% and 79% of patients. Inter-modality concordance ranged between 33-89%. In good surgical outcome patients, PHS, VS, interictal EEG, ictal EEG and HR-ESI showed concordance with resected area in 1/9 (11%), 0/9 (0%), 4/9 (44%), 3/9 (33%) and 6/9 patients (67%). HR-ESI positively impacts clinical management in 50% of patients. CONCLUSIONS: In presurgical evaluation of TSC patients, semiology often has limited localizing value. Presurgical work-up benefits from HR-ESI. SIGNIFICANCE: Our findings may advice future presurgical epilepsy workup of TSC patients with the ultimate aim to improve outcome.


Assuntos
Mapeamento Encefálico/métodos , Encéfalo/fisiopatologia , Epilepsia/fisiopatologia , Cuidados Pré-Operatórios/métodos , Esclerose Tuberosa/fisiopatologia , Adolescente , Adulto , Encéfalo/cirurgia , Criança , Pré-Escolar , Eletroencefalografia , Epilepsia/cirurgia , Feminino , Humanos , Lactente , Masculino , Estudos Retrospectivos , Esclerose Tuberosa/cirurgia , Adulto Jovem
4.
Epilepsia ; 53(10): 1799-809, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22984839

RESUMO

PURPOSE: Epileptic high-frequency oscillations (HFOs; 80-500 Hz) may be used to guide neurosurgeons during epilepsy surgery to identify epileptogenic tissue. We studied the effect of the anesthetic agent propofol on the occurrence of HFOs in intraoperative electrocorticography (ECoG). METHODS: We selected patients who were undergoing surgery for temporal lobe epilepsy with a standardized electrode grid placement. Intraoperative ECoG was recorded at 2,048 Hz following cessation of propofol. The number and distribution of interictal spikes, ripples (R [80-250 Hz]), and fast ripples (FRs; 250-500 Hz) were analyzed. The amount of events on mesiotemporal channels and lateral neocortical channels were compared between patients with a suspected mesiotemporal and lateral epileptogenic area (Student's t-test), and HFOs were compared with the irritative zone, using correlation between amounts of events per channel, to provide evidence for the epileptic nature of the HFOs. Next, the amount of events within the first minute and the last minute were compared to each other and the change in events over the entire epochs was analyzed using correlation analyses of 10 epochs during the emergence periods (Spearman rank test). We studied whether the duration of HFOs changed over time. The change in events within presumed epileptogenic area was compared to the change outside this area (Student's t-test). Periods of burst suppression and continuous background activity were compared between and within patients (t-test). KEY FINDINGS: Twelve patients were included: five with suspected mesiotemporal epileptogenic area and three with suspected lateral epileptogenic area (and four were "other"). Spikes, ripples, and FRs were related to the suspected epileptogenic areas, and HFO zones were related to the irritative zones. Ripples and FRs increased during emergence from propofol anesthesia (mean number of ripples from first minute-last minute: 61.5-73.0, R = 0.46, p < 0.01; FRs: 3.1-5.7, R = 0.30, p < 0.01) and spikes remained unchanged (80.1-79.9, R = -0.05, p = 0.59). There was a decrease in number of channels with spikes (R = -0.18, p = 0.05), but no change in ripples (R = -0.13, p = 0.16) or FRs (R = 0.11, p = 0.45). There was no change in the durations of HFOs. The amount of HFOs in the presumed epileptogenic areas did not change more than the amount outside the presumed epileptogenic area, whereas spikes paradoxically decreased more within the suspected epileptogenic area. Six patients showing burst-suppression had lower rates of ripples than six other patients with continuous background activity (p = 0.02). No significant difference was found between burst suppression and continuous background activity in four patients, but there was a trend toward showing more ripples during continuous background activity (p = 0.16). SIGNIFICANCE: Propofol, known for its antiepileptic effects, reduces the number of epileptic HFOs, but has no effect on spikes. This enforces the hypothesis that, in epilepsy, HFOs mirror the disease activity and HFOs might be useful for monitoring antiepileptic drug treatment. It is feasible to record HFOs during surgery, but propofol infusion should be interrupted for some minutes to improve detection.


Assuntos
Anestésicos Intravenosos , Mapeamento Encefálico , Ondas Encefálicas/efeitos dos fármacos , Epilepsia/fisiopatologia , Período Intraoperatório , Propofol , Adolescente , Adulto , Anestésicos Intravenosos/farmacologia , Criança , Eletroencefalografia , Epilepsia/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Propofol/farmacologia , Adulto Jovem
5.
J Neurosci Methods ; 187(2): 270-9, 2010 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-20109492

RESUMO

Invasive brain signal recordings generally rely on bioelectrodes implanted on the cortex underneath the dura. Subdural recordings have strong advantages in terms of bandwidth, spatial resolution and signal quality. However, subdural electrodes also have the drawback of compromising the long-term stability of such implants and heighten the risk of infection. Epidurally implanted electrodes might provide a viable alternative to subdural electrodes, offering a compromise between signal quality and invasiveness. Determining the feasibility of epidural electrode implantation for e.g., clinical research, brain-computer interfacing (BCI) and cognitive experiments, requires the characterization of the electrical properties of the dura, and its effect on signal feature detection. In this paper we report measurements of brain signal attenuation by the human dura in vivo. In addition, we use signal detection theory to study how the presence of the dura between the sources and the recording electrodes affects signal power features in motor BCI experiments. For noise levels typical of clinical brain signal recording equipment, we observed no detrimental effects on signal feature detection due to the dura. Subdural recordings were found to be more robust with respect to increased instrumentation noise level as compared to their epidural counterpart nonetheless. Our findings suggest that epidural electrode implantation is a viable alternative to subdural implants from the feature detection viewpoint.


Assuntos
Encéfalo/fisiologia , Dura-Máter/fisiologia , Detecção de Sinal Psicológico/fisiologia , Interface Usuário-Computador , Algoritmos , Córtex Cerebral/fisiologia , Interpretação Estatística de Dados , Eletrocardiografia , Eletrodos Implantados , Eletroencefalografia , Eletrofisiologia , Espaço Epidural/fisiologia , Epilepsia/cirurgia , Desenho de Equipamento , Humanos , Processamento de Imagem Assistida por Computador , Individualidade , Processo Mastoide/fisiologia , Córtex Motor/fisiologia , Espaço Subdural/fisiologia
6.
J Magn Reson Imaging ; 30(2): 256-62, 2009 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19629993

RESUMO

PURPOSE: To study 3T compared to 1.5T phased array magnetic resonance imaging (MRI) in the presurgical work-up of patients with epilepsy with complex focus localization. MATERIALS AND METHODS: In all, 37 patients (>10 years) in preoperative work-up for epilepsy surgery were offered 3T in addition to 1.5T MRI if ambiguity existed about the epileptic focus. Scans were randomly reviewed by two observers, blinded for prior imaging, patient-identifying information, and each other's assessments, followed by a consensus meeting. The number of abnormal scans, detected lesions, and interobserver agreement were calculated and compared. The final consensus was compared to original scan reports. RESULTS: One observer identified 22 lesions in both 3 and 1.5T scans, while the second identified more lesions in 1.5T scans (28 vs. 20). 3T MRI had better interobserver agreement. 3T revealed more dysplasias, while 1.5T revealed more tissue loss and mesial temporal sclerosis (MTS). The final consensus yielded 29 lesions, whereas original reports identified only 17 lesions. CONCLUSION: The 3T scans revealed different lesions compared to 1.5T. Patients can benefit most from 3T scans when a dysplasia is suspected. Reevaluation by another experienced neuroradiologist is advised in case of negative or equivocal MRIs.


Assuntos
Epilepsias Parciais/diagnóstico , Imageamento por Ressonância Magnética/métodos , Adulto , Mapeamento Encefálico/métodos , Eletroencefalografia , Epilepsias Parciais/cirurgia , Feminino , Humanos , Masculino , Variações Dependentes do Observador , Seleção de Pacientes
7.
Phys Med Biol ; 54(6): 1673-89, 2009 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-19242052

RESUMO

The simultaneous recording of electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) can give new insights into how the brain functions. However, the strong electromagnetic field of the MR scanner generates artifacts that obscure the EEG and diminish its readability. Among them, the ballistocardiographic artifact (BCGa) that appears on the EEG is believed to be related to blood flow in scalp arteries leading to electrode movements. Average artifact subtraction (AAS) techniques, used to remove the BCGa, assume a deterministic nature of the artifact. This assumption may be too strong, considering the blood flow related nature of the phenomenon. In this work we propose a new method, based on canonical correlation analysis (CCA) and blind source separation (BSS) techniques, to reduce the BCGa from simultaneously recorded EEG-fMRI. We optimized the method to reduce the user's interaction to a minimum. When tested on six subjects, recorded in 1.5 T or 3 T, the average artifact extracted with BSS-CCA and AAS did not show significant differences, proving the absence of systematic errors. On the other hand, when compared on the basis of intra-subject variability, we found significant differences and better performance of the proposed method with respect to AAS. We demonstrated that our method deals with the intrinsic subject variability specific to the artifact that may cause averaging techniques to fail.


Assuntos
Artefatos , Balistocardiografia , Eletroencefalografia/métodos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Humanos
8.
Clin Neurophysiol ; 119(8): 1771-1777, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18495528

RESUMO

OBJECTIVE: To compare nasopharyngeal (NP), cheek and anterior temporal (AT) electrodes for the detection yield and localization of interictal spikes in temporal lobe epilepsy. METHODS: In patients evaluated for epilepsy surgery with subdural electrocorticography electrodes, we simultaneously recorded NP, cheek and AT electrodes. Two observers identified spikes in EEG traces and marked in which channels they occurred. Interobserver agreement was calculated using Cohen's kappa. For localization, data-sets with high interobserver agreement (kappa-value 0.4) were evaluated. The subdural distribution of NP and AT spikes was mapped. RESULTS: Seven patients were included, six were analyzed for localization. Only 1.5% of spikes recorded by cheek electrodes were not seen on temporal leads, while 25% of NP spikes were not seen on either. Spikes only recorded by NP electrodes had mesiobasal, while AT spikes had lateral temporal distribution. CONCLUSIONS: NP electrodes can increase EEG spike detection rate in temporal lobe epilepsy and are more useful than cheek electrodes. Spikes that are seen only on NP electrodes tend to be mesiobasal temporal lobe spikes. SIGNIFICANCE: Adding NP electrodes to scalp EEG can aid interictal spike detection and source localization, especially in short recordings like MEG-EEG.


Assuntos
Bochecha/fisiopatologia , Eletroencefalografia , Epilepsia/patologia , Epilepsia/fisiopatologia , Nasofaringe/fisiopatologia , Espaço Subdural/fisiopatologia , Lobo Temporal/fisiopatologia , Adolescente , Adulto , Mapeamento Encefálico , Criança , Eletrodos , Estudos de Avaliação como Assunto , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
9.
J Clin Neurophysiol ; 19(3): 183-91, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12226563

RESUMO

Epileptiform spikes may have a different morphology and signal-to-noise ratio in simultaneously recorded EEGs and magnetoencephalograms (MEGs) that may lead to differences in the identification of spikes if both the modalities are presented separately. Moreover, there are no criteria for MEG spikes. It is unknown to which extent the visual assessment of MEG data yields consistent and meaningful results. Nineteen patients were selected with mesial temporal lobe epilepsy who underwent whole-head simultaneous MEG/EEG. These data were split into MEG and EEG files and were assessed independently by three observers for the occurrence of spikes. Interobserver kappa values were calculated. A mean kappa value greater than 0.5 was taken as a criterion for the presence of unequivocal spikes. Index cases from the resulting four subgroups were studied further. One patient had unequivocal spikes in both modalities, one in EEG only, one in MEG only, and one did not show any unequivocal spike. Spikes on which at least two observers agreed were then subjected to a template match algorithm to test for equal morphology and distribution. Equal spikes were averaged and electrical and magnetic field maps were plotted. Unequivocal spikes were found in both MEG and EEG in one patient, in MEG only in two patients, in EEG only in two patients, and no spikes in either modality were seen in 14 patients. In the four index patients, MEG showed 50 to 80% more spikes than EEG. After averaging identical consensus spikes, MEG spikes revealed a concomitant spike in the EEG, but the reverse was not always true. Even in the patient with MEG and EEG spikes that met all selection criteria, simultaneous field maps showed unexpected inconsistencies. In most patients with mesial temporal lobe epilepsy, there are no unequivocal spikes during MEG/EEG. In some cases, however, experienced electroencephalographers can identify MEG spikes reliably. Because of a better signal-to-noise ratio, more spikes could be identified in MEG than in EEG. Simultaneous MEG/EEG recordings do not simply ensure the best of both, but one modality may improve the identification of spikes in the other. In addition, different aspects of a complex source can be revealed. Our three-step approach to combined data ensures a reproducible selection of spikes for source modeling.


Assuntos
Potenciais de Ação/fisiologia , Eletroencefalografia/estatística & dados numéricos , Epilepsia do Lobo Temporal/fisiopatologia , Magnetoencefalografia/estatística & dados numéricos , Adulto , Feminino , Humanos , Masculino , Variações Dependentes do Observador
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...