Assuntos
Fibrose Cística , Infecções , Líquido da Lavagem Broncoalveolar , Pré-Escolar , Humanos , Prevalência , Sistema RespiratórioRESUMO
We report a 2-year-old, previously healthy boy, who presented with chronic pneumonia. He was diagnosed with culture-confirmed pulmonary tuberculosis. Complications included spontaneous pneumothorax presumed to be secondary to cavity formation and complete subsegmental airway obstruction that did not resolve with prolonged oral corticosteroid treatment.
Assuntos
Pneumonia/complicações , Pneumotórax/etiologia , Tuberculose Pulmonar/complicações , Antituberculosos/uso terapêutico , Tubos Torácicos , Pré-Escolar , Glucocorticoides/uso terapêutico , Humanos , Masculino , Pneumotórax/terapia , Tuberculose Pulmonar/tratamento farmacológicoRESUMO
It is unclear whether the failure to reverse bronchoconstriction with deep inspiration (DI) in asthma is due to reduced maximal dilatation of the DI. We compared the effect of different DI volumes on maximal dilatation and reversal of bronchoconstriction in nine asthmatics and ten non-asthmatics. During bronchoconstriction, subjects took DI to 40%, 70% and 100% inspiratory capacity, on separate days. Maximal dilatation was measured as respiratory system resistance (Rrs) at end-inspiration and residual dilatation as Rrs at end-expiration, both expressed as percent of Rrs at end-tidal expiration prior to DI. DI volume was positively associated with maximal dilatation in non-asthmatics (ANOVA p=0.055) and asthmatics (p=0.023). DI volume was positively associated with residual dilatation in non-asthmatics (p=0.004) but not in asthmatics (p=0.53). The degree of maximal dilatation independently predicted residual dilatation in non-asthmatics but not asthmatics. These findings suggest that the failure to reverse bronchoconstriction with DI in asthma is not due to reduced maximal dilatation, but rather due to increased airway narrowing during expiration.
