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2.
Wien Med Wochenschr ; 172(3-4): 57-58, 2022 03.
Artigo em Alemão | MEDLINE | ID: mdl-32821989
3.
Wien Med Wochenschr ; 172(9-10): 195-197, 2022 06.
Artigo em Alemão | MEDLINE | ID: mdl-33570694
4.
Wien Med Wochenschr ; 172(7-8): 149-150, 2022 05.
Artigo em Alemão | MEDLINE | ID: mdl-33512622
5.
Wien Med Wochenschr ; 172(13-14): 287-289, 2022 10.
Artigo em Alemão | MEDLINE | ID: mdl-33738634
6.
Wien Med Wochenschr ; 171(9-10): 195-197, 2021 06.
Artigo em Alemão | MEDLINE | ID: mdl-32472320
7.
Wien Med Wochenschr ; 171(11-12): 243-244, 2021 09.
Artigo em Alemão | MEDLINE | ID: mdl-32642879
8.
Wien Med Wochenschr ; 171(3-4): 44-47, 2021 03.
Artigo em Alemão | MEDLINE | ID: mdl-32144685
9.
Wien Med Wochenschr ; 171(7-8): 145-147, 2021 05.
Artigo em Alemão | MEDLINE | ID: mdl-32215770
11.
Med Phys ; 48(1): 505-512, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33222211

RESUMO

PURPOSE: To design and commission a water phantom suitable for constrained environments and magnetic fields for magnetic resonance (MR)-guided proton therapy. METHODS: A phantom was designed, to enable precise, remote controlled detector positioning in water within the constrained environment of a magnet for MR-guided proton therapy. The phantom consists of a PMMA enclosure whose outer dimensions of 81 × 40 × 12.5 cm 3 were chosen to optimize space usage inside the 13.5-cm bore gap of the magnet. The moving mechanism is based on a low-height H-shaped non-ferromagnetic belt drive, driven by stepper motors located outside of the magnetic field. The control system and the associated electronics were designed in house, with similar features as available in commercial water phantoms. Reproducibility as well as accuracy of the phantom positioning were tested using a high-precision Leica AT 402 laser tracker. Laterally integrated depth dose curves and lateral beam profiles at three depths were acquired repeatedly for a 148.2 MeV proton beam in water. RESULTS: The phantom was successfully operated with and without applied magnetic fields. For complex movements, a positioning uncertainty within 0.16 mm was found with an absolute accuracy typically below 0.3 mm. Laterally integrated depth dose curves agreed within 0.1 mm with data taken using a commercial water phantom. The lateral beam offset determined from beam profile measurements agreed well with data from Monte Carlo simulations. CONCLUSION: The phantom is optimally suited for detector positioning and dosimetric experiments within constrained environments in high magnetic fields.


Assuntos
Terapia com Prótons , Prótons , Campos Magnéticos , Método de Monte Carlo , Imagens de Fantasmas , Radiometria , Reprodutibilidade dos Testes , Água
12.
Stem Cell Res ; 48: 101951, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32798915

RESUMO

Dermal fibroblasts from a patient carrying a heterozygous c.88G > C mutation in the SNCA gene that encodes alpha-synuclein were reprogrammed to pluripotency by retroviruses. This pathogenic mutation generates the p.A30P form of the alpha-synuclein protein leading to autosomal dominantly inherited Parkinson's disease (PD). Two clonal iPS cell lines were generated (A30P-3 and A30P-4) and characterised by validating the silencing of viral transgenes, the expression of endogenous pluripotency genes, directed differentiation into three germ layers in-vitro and a stable molecular genotype. These iPSC lines will serve as a valuable resource in determining the role of the p.A30P SNCA mutation in PD pathogenesis.


Assuntos
Células-Tronco Pluripotentes Induzidas , Doença de Parkinson , Linhagem Celular , Humanos , Mutação/genética , Doença de Parkinson/genética , alfa-Sinucleína/genética
13.
Wien Med Wochenschr ; 170(7-8): 152-154, 2020 05.
Artigo em Alemão | MEDLINE | ID: mdl-32270370
14.
Wien Med Wochenschr ; 170(13-14): 325-328, 2020 10.
Artigo em Alemão | MEDLINE | ID: mdl-32016591
16.
17.
18.
Wien Med Wochenschr ; 169(13-14): 307-311, 2019 10.
Artigo em Alemão | MEDLINE | ID: mdl-31463618
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