1.
Angew Chem Int Ed Engl
; 51(31): 7812-6, 2012 Jul 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22715146
RESUMO
Probing the depths: A tandem post-polymerization modification strategy was used to systematically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see scheme), carbohydrate density, and glycopolymer chain length. Guided by structural-biology information, the binding-pocket depth of the toxin was probed and used as a means to specifically improve inhibition of the toxin by the glycopolymer.