Substance Use and Childhood Sexual Abuse among Girls Who Are Victims of Commercial Sexual Exploitation.

Background: Girls who are victims of commercial sexual exploitation (CSEC) have high rates of substance use and childhood sexual abuse. We compared girls who are victims of CSEC and matched controls on childhood sexual abuse and substance use, and examined if substance use is associated with increased CSEC odds. Methods: Data were retrospectively collected from assessments completed by 80 girls who were referred by the Department of Child Services (Mage=15.38, SD=1.3, 51.9%White). Results: CSEC girls reported higher substance use (t=-2.76, p=.007), and were more likely report childhood sexual abuse (χ2=6.85, p=.009). The relationship between childhood sexual abuse and substance use outcomes did not differ across the groups (b's 0.12-1.38, p's .22-.85). Substance use disorder diagnosis was associated with greater odds of being in the CSEC group (ORs 2.95-6.72, p's<.05). Conclusions: Substance use and childhood sexual abuse are important risk indicators for exploitation, but should not be used to reduce criminality of CSEC perpetrators.

Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency.

Negative urgency is a personality trait reflecting the tendency to act rashly in response to extreme negative emotions and is considered a transdiagnostic endophenotype for problematic levels of addictive behaviors. Recent research has begun to identify the neural correlates of negative urgency, many of which appear to overlap with neural circuitry underlying addictive disorders associated with negative urgency. The goal of this qualitative review is to summarize the extant literature concerning the neural correlates of negative urgency, to compare these correlates with those implicated with addictive disorders, and to propose new ways to begin to leverage such findings in treatment and intervention approaches. We also address current limitations in the field and make recommendations for areas for future growth in this research domain. Patterns of structure and function in the ventral striatum, frontal regions, such as the prefrontal cortex (PFC) and orbitofrontal cortex (OFC), and amygdala are common across addictive disorders and are related to both real-world risky behaviors and self-report measures of negative urgency. We propose that the time has come to move past considering this trait and these disorders as completely separate entities, and instead for the field to consider how general patterns of convergence across these disorders can lead to a more transdiagnostic approach to treatment and intervention. We suggest future work utilize these convergent patterns in the development of animal models of negative urgency, in the identification and testing of prime pharmacological and physiological interventions, and as objective biomarkers to be used when testing behavioral, pharmacological, and physiological intervention effectiveness. Little empirical work has been done to date in these areas and advances in these nascent fields would advance understanding and applications of the neuroscience of negative urgency.