Two cases of Kawasaki disease: Clinical characteristics and onset of fever and gastrointestinal symptoms.

BACKGROUND: Kawasaki disease (KD) is a prevalent form of systemic vasculitis that can damage various organs and systems in children. Typical KD is not difficult to diagnose in clinical practice. In recent years, it has been shown that an increasing number of children do not satisfy the diagnostic criteria for typical KD. This condition is known as incomplete KD (IKD). It is challenging to promptly diagnose and treat such children in clinical practice. CASE DESCRIPTION: A 10-year-old girl was admitted to the hospital due to fever and abdominal pain. She presented with shock symptoms. An enhanced abdominal computed tomography scan revealed intestinal pneumatosis, effusion, and gallbladder enlargement, indicating intestinal obstruction. Due to the poor outcome following an emergency laparoscopic cholecystectomy, IKD was suspected. A 3-month-old male pediatric patient was admitted to the hospital due to a fever. Patchy, congestive rashes formed on the patient's body as KD progressed. IKD was suspected based on the clinical signs of fever, rash, and hyperemia of the lips. The two patients were then treated with human immunoglobulin and aspirin treatment. The prognosis for the two children was favorable following prompt treatment. CONCLUSION: Due to the fact that IKD is frequently misdiagnosed, it is vital to (1) improve the patient prognosis for the early identification of children with KD with prolonged fever and anti-infection failure as the initial manifestation and (2) perform timely diagnosis and comprehensive treatment.

Two new compounds from the roots of Scrophularia ningpoensis and their anti-inflammatory activities.

Aiming to investigate the bioactive constituents with anti-inflammatory activity from the roots of Scrophularia ningpoensis, two new compounds (1 and 3) were isolated from the extract of the roots of the plant. Their structures were elucidated on the basis of spectral analyses (UV, IR, NMR, and MS spectroscopy), as well as experimental and calculated electronic circular dichroism (ECD) analyses. All of the isolates were tested for their anti-inflammatory properties in terms of suppressing the production of NO in lipopolysaccharide-induced BV2 cells. Compound 2 exhibited stronger anti-inflammatory effects (77.65%) than the positive control curcumin (69.75%) at 10 µM.

[INT-ETS activity change of activated sludge during nitrification, denirification and organism removal in SBR process].

Through nitrogen shock loading and organic shock loading experiments, we studied the changing rule and activity status of biological activity of activated sludge in organic matter biodegradation, nitrification and denitrification course in SBR process by the determination of INT-ETS activity. The experimental results show that INT-ETS activity could provide a good indication of the ongoing biological reactions of SBR process. Biological activity of organic matter biodegradation, nitrification and denitrification course in SBR process reduced orderly. INT-ETS activity reduced from 232.59 mg/(gxh) to 190.65 mg/(gxh) and resultly to 113.88 mg/(gxh) when the effluent concentration of COD and NH4(+)-N were 300 mg/L and 40 mg/L. Nitrogen shock loading (14.5 mg/L and 42.0 mg/L) and organic shock loading (COD are 293 mg/L and 685 mg/L) experiments cure verify that the operational conditions could not influence the changing rule of INT-ETS activity, but the time of the appearance of break points marking different reaction course in profile was influenced.