RESUMO
An anhydrous ethyl alcohol solution of aluminum chloride in a 6.25% concentration has been demonstrated to be a highly effective local treatment of chronic folliculitis, especially of the buttocks.
Assuntos
Compostos de Alumínio , Alumínio/administração & dosagem , Cloretos , Foliculite/tratamento farmacológico , Administração Tópica , Adulto , Idoso , Cloreto de Alumínio , Doença Crônica , Feminino , Furunculose/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Sudorese/efeitos dos fármacosRESUMO
A new topical approach to acne treatment--the use of aluminum chloride hexahydrate in anhydrous ethanol (ACAE)--was studied in 141 patients. Using sequential treatment schedules, paired comparison techniques, and various concentrations of ACAE, we established maximal efficacy with minimal local irritation for the 6.25% strength solution. Clinical efficacy and lack of toxicity of this formulation were confirmed by the additional clinical study of 65 patients. The antiperspirant and antibacterial actions of 6.25% ACAE solution were then verified on acne skin areas. It is postulated that the clinical improvement in acne that follows the topical use of ACAE results from one or both of these actions.
Assuntos
Acne Vulgar/tratamento farmacológico , Alumínio/uso terapêutico , Sudorese/efeitos dos fármacos , Acne Vulgar/microbiologia , Acne Vulgar/fisiopatologia , Administração Tópica , Adolescente , Adulto , Alumínio/administração & dosagem , Alumínio/farmacologia , Anti-Infecciosos , Composição de Medicamentos , Etanol , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , SoluçõesRESUMO
Axillary hyperhidrotics is reviewed from the standpoint of anatomical factors, physiological mechanisms and the history of methods of control. Anhydrous aluminum chloride and anhydrous zirconium tetrachloride are shown to be superior topical agents for partial control of axillary sweating when applied as a powder or in anhydrous nonreactive vehicles. Complete anhidrosis as demonstrated by sustained garment armpit dryness could be achieved in hyperhidrotics within 48 hours by the following trinary antiperspirant system: (1) a saturated solution of aluminum chloride hexahydrate or zirconyl chloride in absolute ethanol or isopropyl alcohol, (2) application to the dry axilla at times of sleep or other prolonged non-sweating period, (3) water vapor occlusion of area for 6 to 8 hours by means of Saran wrap. The hypothesis is presented that metallic antiperspirants act by reflux entrance into the terminal intraepidermal eccrine duct, slowly combining with the intraductal keratin, to produce a fibrillar contraction (super contraction) of keratin and hence functional closure, not histologically evident. This altered keratin is shed weeks later, with the consequent return of ductal patency and sweating.
