RESUMO
The purpose of this study was to demonstrate the potential of MRI for guiding, monitoring, and evaluating endovascular interventions. This was done by investigating the feasibility of MR-guided balloon angioplasty in a stenosed vessel model. Catheters and guidewires were prepared for susceptibility-based MR visualization by incorporating paramagnetic markers into their walls. Near real-time monitoring (up to 1 image/sec) of the interventional procedure was achieved by using a dynamic two-dimensional gradient-echo technique. Devices were localized by on-the-fly subtraction of a baseline image from consecutive dynamic images and by merging the subtraction images with a previously acquired road map. All steps involved in balloon angioplasty, from the introduction and placement of a guidewire to the positioning of a catheter across the stenosis, inflation of the balloon, and dilatation of the stenosis could adequately be monitored with MR fluoroscopy. The beneficial effect of dilatation could be substantiated by a reduction of stenosis-related hypointensities and hyperintensities in the posttreatment MR angiogram as compared to the pretreatment angiogram and by a posttreatment increase of the volumetric flow rate.
Assuntos
Angioplastia com Balão/métodos , Angiografia por Ressonância Magnética/métodos , Imageamento por Ressonância Magnética/métodos , Constrição Patológica/terapia , Estudos de Viabilidade , Humanos , Modelos Cardiovasculares , Radiologia Intervencionista/métodosRESUMO
In a 47-year-old healthy male volunteer, susceptibility-based magnetic resonance (MR) imaging was performed in the basilic vein in the right upper arm at 1.5 T. A conventional 3-F nonbraided polyethylene catheter with a 0.3-mm lumen diameter was locally impregnated with dysprosium oxide, and six ringed areas of increased susceptibility were created. passive tracking of the catheter was performed with near-real-time conventional two-dimensional gradient-echo angiography. The entire prepared part of the catheter was depicted without steering problems or complications. Passive tracking is expected to provide a valuable adjunct to active tracking for guiding endovascular interventions.