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1.
J Int Assoc Provid AIDS Care ; 16(2): 201-208, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-23422744

RESUMO

Identification of broadly neutralizing antibodies (NAbs) generated during the course of HIV-1 infection is essential for effective HIV-1 vaccine design. The magnitude and breadth of neutralizing activity in the sera from 46 antiretroviral treatment-naive HIV-1 clade C-infected individuals was measured in a single round infection assay using TZM-bl cells and multisubtype panel of env-pseudotyped viruses. Higher levels of NAb response (NAb titer 500 to >40 000) were measured in these patients against tier 1 and tier 2 viruses. The average magnitude of the NAb responses of chronically infected individuals against heterologous viruses was consistently higher than the response observed from individuals with long-term nonprogressor ( P = .086). To conclude, high titers of HIV-1 cross-neutralizing activity were observed in the sera from a subset of HIV-1-infected individuals in Chennai, India. Additional studies of the epitopes recognized by these antibodies may facilitate the discovery of an effective vaccine immunogen.


Assuntos
Anticorpos Neutralizantes/sangue , Anticorpos Anti-HIV/sangue , Infecções por HIV/epidemiologia , Infecções por HIV/imunologia , HIV-1/imunologia , Adulto , Contagem de Linfócito CD4 , Estudos de Coortes , Reações Cruzadas , Humanos , Testes de Neutralização , RNA Viral/sangue
2.
J Coll Physicians Surg Pak ; 24 Suppl 1: S52-4, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24718008

RESUMO

A 34 years old non-smoker male patient reported with growth of right maxillary region which on histopathology confirmed adenosquamous carcinoma of nose and paranasal sinus. Patient also had total situs inversus including dextrocardia, bronchiectasis and sinusitis. His blood group was AB negative. This association of Kartagener syndrome with adenosquamous carcinoma of paranasal sinuses has never been reported. Carcinoma of paranasal sinuses accounts only 0.3% of all cancers. Adenosquamous carcinoma makes only 2% of the nose and paranasal sinuses tumours. Kartagener syndrome, AB negative blood group and adenosquamous carcinoma of paranasal sinuses all are extremely rare clinical conditions found in populations and the combination of all three in the same patient have never been reported to the best of authors' knowledge.


Assuntos
Carcinoma Adenoescamoso/patologia , Síndrome de Kartagener/diagnóstico , Neoplasias dos Seios Paranasais/patologia , Seios Paranasais/patologia , Adulto , Evolução Fatal , Humanos , Síndrome de Kartagener/cirurgia , Imageamento por Ressonância Magnética , Masculino , Procedimentos Cirúrgicos Nasais , Situs Inversus/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Ultrassonografia
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