RESUMO
Modern anthelmintic use in horses has decreased the prevalence of the large strongyles, which has in turn shifted the focus of parasitologists to the pathogenic importance of the small strongyles, tapeworms, and other parasites. These studies show that a combination product containing ivermectin and praziquantel allowed efficacious treatment of horses for nematode, cestode, and bot infections. The use of this combination product may be of special benefit to horses that are mainly kept outdoors and on grazing pastures.
Assuntos
Anti-Helmínticos/uso terapêutico , Doenças dos Cavalos/tratamento farmacológico , Ivermectina/uso terapêutico , Praziquantel/uso terapêutico , Infecções Equinas por Strongyloidea/tratamento farmacológico , Administração Oral , Animais , Anticestoides/uso terapêutico , Antinematódeos/uso terapêutico , Infecções por Cestoides/tratamento farmacológico , Infecções por Cestoides/veterinária , Relação Dose-Resposta a Droga , Quimioterapia Combinada , Feminino , Helmintíase Animal/tratamento farmacológico , Doenças dos Cavalos/parasitologia , Cavalos , Masculino , Infecções por Nematoides/tratamento farmacológico , Infecções por Nematoides/veterinária , Distribuição Aleatória , Estrongilídios/efeitos dos fármacos , Resultado do TratamentoRESUMO
The safety and efficacy of 2% moxidectin/12.5% praziquantel oral gel administered at a rate of 0.4 mg moxidectin and 2.5 mg praziquantel/kg was studied in client-owned horses under field use conditions. Four hundred horses (300 treated with moxidectin/praziquantel oral gel and 100 treated with vehicle) were enrolled, feces were collected, and eggs were counted. Investigators as well as horse owners were masked to treatment assignment. No adverse reactions to treatment were observed in any horses. Moxidectin/praziquantel gel reduced Anoplocephala spp by more than 99% and provided a significant (P <.05) reduction (> 98%) in the strongyle egg count of treated horses.
