Assuntos
Fabaceae/efeitos adversos , Favismo/etiologia , Deficiência de Glucosefosfato Desidrogenase/complicações , Glucosefosfato Desidrogenase/sangue , Hemólise , Plantas Medicinais , Adulto , Diagnóstico Diferencial , Favismo/enzimologia , Favismo/etnologia , Glucosefosfato Desidrogenase/genética , Deficiência de Glucosefosfato Desidrogenase/genética , Humanos , Iraque/etnologia , MasculinoRESUMO
Pure red cell aplasia was observed in a 28 year old woman following a major ABO mismatched allogeneic bone marrow transplant for chronic lymphocytic leukemia. No evidence of red blood cell production was observed for more than one year following transplant despite the absence of high isohemagglutinin titers. Treatment with antithymocyte globulin resulted in prompt restoration of reticulocytosis. Therapy with antithymocyte globulin should be considered in these instances when red cell aplasia follows mismatched allogeneic marrow transplantation.
Assuntos
Sistema ABO de Grupos Sanguíneos , Soro Antilinfocitário/uso terapêutico , Transplante de Medula Óssea/efeitos adversos , Histocompatibilidade , Leucemia Linfocítica Crônica de Células B/cirurgia , Aplasia Pura de Série Vermelha/etiologia , Linfócitos T/imunologia , Sistema ABO de Grupos Sanguíneos/genética , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Clorambucila/administração & dosagem , Terapia Combinada , Feminino , Humanos , Isoanticorpos/imunologia , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Núcleo Familiar , Prednisona/administração & dosagem , Aplasia Pura de Série Vermelha/terapia , Transplante Homólogo/efeitos adversosRESUMO
Peripheral blood mononuclear cells from 11 patients with remission Hodgkin disease and 20 normal controls were incubated with irradiated allogeneic lymphocytes in one-way mixed lymphocyte cultures. Simultaneously, modified assays were performed by adding supplemental irradiated PBM, T lymphocytes, or adherent cells autologous to the responders. Baseline allogeneic responsiveness of patients and controls was not different. However, significant suppression (p less than .01) was demonstrated when the cultures were supplemented with patient mononuclear cells or adherent cells, an effect not found with similar supplemental cells from controls. Conversely, T-cell supplementation of control cultures produced more than twofold increases in proliferation but significantly less augmentation in the patients' cultures (p less than .01). T-cell subset analysis in six patients showed decreased helper: suppressor cell ratios. Hodgkin disease patients have adherent suppressor cells, which persist during remission, as well as a defect in T-cell helper function.
