1.
Bioorg Med Chem Lett
; 18(2): 568-70, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18068361
RESUMO
A series of gem-dialkyl naphthalenone derivatives with varied alkyl substitutions were synthesized and evaluated according to their structure-activity relationship. This investigation led to the discovery of potent inhibitors of the hepatitis C virus at low nanomolar concentrations in both enzymatic and cell-based HCV genotype 1a assays.