Cytotoxic and anti-inflammatory activities of secondary metabolites from Ophiorrhiza baviensis growing in Thua Thien Hue, Vietnam.

A new ursane-type triterpene, 3ß,23,24-trihydroxyurs-12-en-28-oic acid (1), together with eight known compounds (2-9) were isolated from the aerial parts of Ophiorrhiza baviensis. Among them, compounds 2-5 were found for the first time from the genus Ophiorrhiza, while compounds 6-9 were reported from O. baviensis for the first time. Their structures were elucidated by analysis of HR-ESI-MS and NMR (1H-NMR, 13C-NMR, HSQC, and HMBC) spectra, as well as comparison with those reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against MCF-7, Hela, KB, A549, and SK-LU-1 cancer cell lines and their effects on LPS-induced NO production in RAW264.7 cells. This is the first report of chemical constituents and biological activities of O. baviensis.

Identification Of Potential Cytotoxic Inhibitors From Physalis Minima.

A phytochemical investigation of Physalis minima led to the isolation of six withanolides, including withanolide E (1), withaperuvin C (2), 4ß-hydroxywithanolide E (3), 28-hydroxywithaperuvin C (4), physaperuvin G (5), and 4-deoxywithaperuvin (6). Their chemical structures were elucidated by 1 D-NMR and 2 D-NMR data, as well as comparison with the data reported in the literature. All isolated compounds were evaluated for their cytotoxic activity against HepG2, SK-LU-1, and MCF7 cancer cell lines. As the obtained results, compounds 1 and 3 displayed the strongest cytotoxicity against HepG2, SK-LU-1, and MCF7 cell lines with IC50 value ranging from 0.051 ± 0.004 to 0.86 ± 0.09 µg/mL.

Cytotoxic activity of steroidal glycosides from the aerial parts of Solanum torvum collected in Thua Thien Hue, Vietnam.

A phytochemical investigation of Solanum torvum led to the isolation of eleven steroidal glycosides, including neochlorogenin 6-O-ß-D-quinovopyranoside (1), (22 R,23S,25R)-3ß-6α,23-trihydroxy-5α-spirostane 6-O-ß-D-xylopyranosyl-(1→3)-ß-D-quinovopyranoside (2), neochlorogenin 6-O-α-L-rhamnopyranosyl-(1→3)-ß-D-quinovopyranoside (3), solagenin 6-O-α-L-rhamnopyranosyl-(1→3)-ß-D-quinovopyranoside (4), paniculonin A (5), paniculonin B (6), 6α-O-[ß-D-xylopyranosyl-(1→3)ß-D-quinovopyranosyl]-(25S)-5α-spirostan-3ß-ol (7), torvoside J (8), torvoside K (9), torvoside L (10) and solagenin 6-O-ß-D-quinovopyranoside (11). Their chemical structures were elucidated by 1D-NMR and 2D-NMR data as well as comparison with the data reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against SK-LU-1, HepG2, MCF-7 and T24 cancer cell lines. Among them, compounds 1, 3, 7 and 11 exhibited cytotoxicity against all four tested cell lines with IC50 values ranging from 7.89 ± 0.87 to 46.76 ± 3.88 µM.