RESUMO
Historically patients with advanced basal cell carcinoma have been subjected to large surgical resections for the treatment of their disease. However, with the development of vismodegib, a first in class molecule that acts to inhibit the hedgehog pathway, patients with advanced and metastatic basal cell carcinoma may have renewed hope in limiting the morbidity involved with surgery. Preliminary data shows a relatively good safety profile and promising results, although further research remains to be conducted. Current progress on utilization of vismodegib for the treatment of advanced basal cell carcinoma is reviewed in this article. Only literature with objective clinical evidence was included in this review.
Assuntos
Anilidas/uso terapêutico , Carcinoma Basocelular/tratamento farmacológico , Piridinas/uso terapêutico , Anilidas/administração & dosagem , Ensaios Clínicos como Assunto , Humanos , Masculino , Piridinas/administração & dosagemRESUMO
OBJECTIVES/HYPOTHESIS: To demonstrate the efficacy of the hedgehog pathway inhibitor GDC-0449 in the treatment of advanced basal cell carcinoma. DESIGN STUDY: Case series. METHODS: Three patients treated in a referral center for locally advanced basal cell carcinoma, one with metastases, were referred for treatment in a GDC-0449 phase I clinical trial. The treatment was once per day continuous therapy with oral GDC-0449. RESULTS: Two patients showed complete clinical and radiologic resolution of disease, whereas one patient had significant reduction in tumor burden with radiologic evidence of slowly progressive local disease. Side effects were taste changes, mild to moderate hair loss, and muscle cramps in one patient. CONCLUSIONS: GDC-0449 showed significant inhibitory activity in the treatment of advanced basal cell carcinoma.
Assuntos
Anilidas/uso terapêutico , Carcinoma Basocelular/tratamento farmacológico , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Proteínas Hedgehog/antagonistas & inibidores , Piridinas/uso terapêutico , Adulto , Biópsia , Carcinoma Basocelular/diagnóstico , Carcinoma Basocelular/metabolismo , Diagnóstico Diferencial , Feminino , Seguimentos , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/metabolismo , Proteínas Hedgehog/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Resultado do TratamentoAssuntos
Carcinoma Basocelular/cirurgia , Neoplasias Palpebrais/cirurgia , Neoplasias Faciais/cirurgia , Secções Congeladas/métodos , Neoplasias Cutâneas/cirurgia , Procedimentos Cirúrgicos Operatórios/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Carcinoma Basocelular/epidemiologia , Carcinoma Basocelular/patologia , Diagnóstico Diferencial , Neoplasias Palpebrais/epidemiologia , Neoplasias Palpebrais/patologia , Neoplasias Faciais/epidemiologia , Neoplasias Faciais/patologia , Feminino , Seguimentos , Humanos , Incidência , Período Intraoperatório , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/epidemiologia , Recidiva Local de Neoplasia/patologia , Estudos Retrospectivos , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Fatores de Tempo , Resultado do Tratamento , Estados Unidos/epidemiologia , Adulto JovemRESUMO
OBJECTIVE: To describe new applications for the dorsal nasal flap technique of facial reconstruction. METHODS: Retrospective review of surgical records of patients in whom the dorsal nasal flap technique was used. RESULTS: The dorsal nasal flap technique was used in 61 patients to repair defects ranging in size from 12 x 17 mm to 35 x 40 mm. CONCLUSION: The dorsal nasal flap technique is more versatile than has been traditionally appreciated and can allow single-stage reconstruction of many sizes of defects affecting various areas of the nose.
Assuntos
Rinoplastia/métodos , Retalhos Cirúrgicos , Humanos , Estudos Retrospectivos , Resultado do TratamentoRESUMO
We report on two young adults with KID syndrome and follicular hyperkeratosis, hidradenitis suppurativa of the groin, progressive development of proliferative pilar cysts and dissecting cellulitis of the scalp, who developed metastatic malignant pilar tumors. Based on our findings, we believe that cancer surveillance in patients with KID syndrome should include screening for pilar tumors and their early removal to avoid development of malignant proliferating pilar tumors with poor prognosis.
