A Case of Extensive Necrosis of the Gastric Mucosa Following Ethanol Injection Therapy / 대한소화기내시경학회지

A bleeding peptic ulcer is the most common cause of upper gastrointestinal bleeding as well as for hospitalization and death. Many endoscopic methods of treating bleeding peptic ulcers are currently being studied and developed. Among them, the endoscopic pure ethanol injection therapy is favored because of its high efficacy, low cost, and rapid administration. Pure ethanol is an excellent agent to stop bleeding and manifests itslef by inducing tissue dehydration, fixation and vessel compression, which in turn causes arterial coagulation and tissue necrosis. However, an excessive injection volume may bring about extensive mucosal necrosis; hence, caution should be taken when deciding upon the injection volume and depth. We report a case of extensive necrosis of the gastric mucosa following endoscopic ethanol injection therapy of a bleeding peptic ulcer along with a review of the relevant literature.

A Case of Systemic Sclerosis Combined with Ovarian Cancer / 대한류마티스학회지

We report a 54-year old female who had mild dyspnea, coughing, abdominal distension, tightening and thickening of the skin, and Raynaud's phenomenon. Clinical manifestations, laboratory and radiologic examinations were compatible with systemic sclerosis. She was also diagnosed to have ovarian cancer on histopathologic study. The possible causative relation between systemic sclerosis and malignant neoplasms is a controversial issue, but several studies have demonstrated an increased frequency of cancer in patients with systemic sclerosis, especially lung and breast cancers. Ovarian cancer was rarely reported in association with systemic sclerosis. We present this case with a review of literatures.