[Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]. / Preduprezhdenie izotiobarbaminom narushenii uglevodnogo, kislorodnogo obmena i razvitiia oteka mozga v rannie sroki posle vnutrimozgovogo krovoizliianiia.

In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats.

[Use of isothiobarbamin in the correction of disorders of the vital activities of the brain in intracerebral hemorrhage]. / Korrektsiia izotiobarbaminom narushenii zhiznedeiatel'nosti mozga pri vnutrimozgovom krovoizliianii.

Isothiobarbamin injected intravenously to cats in the phase of circulatory hypoxia 1-2 days after intracerebral hemorrhage improves the functional activity, blood supply, oxygen supply to the brain, prevents excessive accumulation of lactate in the brain tissue. The drug exerts the stimulating effect on the disordered local blood flow: the blood supply to the ischemic areas increases, and that of the hyperemic ones decreases. The mechanism of the vasodilative effect of isothiobarbamin is due to inhibition of Ca2+ delivery through the potential-dependent and serotonin-activated channels of the smooth muscle plasmic membrane. The drug activity increases with a rise of the initial vascular tone.