[Creatine kinase BB and lactate in the cerebrospinal fluid of neonates and infants with perinatal injuries of the CNS]. / Kreatinkinaza-BB i laktat v spinnomozgovoi zhidkosti u novorozhdennyki u detei rannego vozrasta s perinatal'nymi porazheniiami TsNS.

A study was made of the content of creatine kinase-BB (CK-BB) and lactate in cerebrospinal fluid (CSF) of 202 neonates and infants with perinatal CNS injuries. The relationship was found between the rise of the CK-BB content and the gravity of perinatal CNS injuries. The highest content of CK-BB in CSF was marked in neonates with cerebral disorders complicated by infectious and inflammatory diseases (pneumonia, sepsis). Within the first 5 days of life, the children of this group demonstrated the relationship between the content of CK-BB and lactate of CSF. The measurement of the content of CK-BB in CSF should be used for early diagnosis, assessment of the gravity and course of perinatal CNS injuries in neonates and in infants.

[Significance of risk factors in the development and formation of permanent organic lesions of the central nervous system in infants during the 1st few months of life]. / Znachenie faktorov riska vozniknoveniia i formirovaniia stoikogo organicheskogo porazheniia tsentral'noi nervnoi sistemy u detei pervykh mesiatsev zhizni.

Data obtained from examining 350 full-term newborns and infants of up to 4 months of age with pre- and perinatal encephalopathies were processed mathematically. As a result, factors pointing to a high risk of development of functional cerebral disorders and formation of early organic syndromes in infants of the first 4 months of life were specified. As the basis for this a chart devised with the aid of the expert evaluation method was taken. The chart included 42 signs with 98 gradations (occupational unhealthy factors, family and obstetrical history, course of pregnancy and childbirth, clinical characteristics of the neurological manifestations in the acute and early restorative periods). A high prognostic value of combining some factors, symptom complexes, clinical and laboratory findings is demonstrated: such combinations are very important for early diagnosis of organic cerebral pathologies. The use of those combinations has made it possible to identify (with the aid of a computer) 95.6% of infants with a threat of early development of organic changes in the central nervous system.

[Diagnosis and course of convulsive states in children]. / O diagnostike i techenii sudorozhnykh sostoianii u detei.

In 129 children convulsive states were examined with the use of a set of additional examination methods. The age structure of the convulsions and their course in young children are described. Different origin of the convulsive states is shown. The role of pre- and perinatal factors, mineral metabolism disturbances, infectious and other diseases, as well as of aggravated heredity is demonstrated. The importance of the premorbid background for the formation of the character and the course of the convulsive seizures in children, and for the formation of epileptiform syndrome is stressed.

[Incidence of neurologic diseases in children]. / O rasprostranennosti nevrologi cheskikh zabolevanii u detei.

Data concerning the distribution and the nosological structure of nervous diseases in children aged from one month to 14 years in the town of N. (76 thousand inhabitants, 16,716 children) are presented. Peculiarities of the dynamics of the disease entities with reference to the age, as well as the influence of the sex on the disease entity are shown. Ranging of the distribution data has made it possible to fix the principal rank places for individual disease entities. The data obtained served as basis for calculating the requirements for neurological beds in children's hospitals and other specialized medical institutions for children.

[The pathogenesis of the convulsion syndrome in children]. / K patogenezu sudorozhnogo sindroma u detei

The report contains some results of clinical, biochemical and EEG studies convened in 24 children with convulsive attacks and in 34 children with organic lesions of the CNS and epileptiform syndromes. The authors point out to the important role of the diencephalic area in the pathogenesis of convulsive syndromes. Changes in the glucocortical functions of the adrenal system during the period of convulsive attacks are related to a disturbed regulation in the hypothalamo-hypophysar structure. The processes of readaptation are more disturbed in patients with organic lesions of the CNS in frequent attacks. The results of such studies speak of certain indications to hormone therapy in repeated convulsions in children, especially if the convulsions have an epileptiform character and occur in patients with organic lesions of the CNS.