[Biochemical and morphological changes in white rat lung and liver tissues in experimental paraquat poisoning]. / Biokhminicheskie i morfologicheskie izmeneniia v tkaniakh legkikh i pecheni belykh krys pri éksperimental'noi intoksikatsii parakvatom.

Superoxide dismutase (SOD) activity, the number of free radicals and pathomorphological changes were studied in lung and liver tissues of white rats with experimental paraquat poisoning. It was shown that SOD activity in the lungs and liver decreased and the number of free radicals rose. The inhibition of SOD activity after repeated administration of paraquat (1/10 of LD50) was more pronounced than in acute poisoning. Dystrophic and proliferative histomorphological changes characteristic for acute and chronic experiments and disturbed vascular permeability were revealed. It is suggested that the toxic action of paraquat on the animals is particularly consequent on the lack of SOD activity and enhancement of free radical processes.

[NADPH-dependent oxidation in endoplasmic reticulum of rat liver after valexon administration]. / NADRN-zavisimoe okislenie v endoplazmaticheskom retikulume pecheni krys pri vvedenii valeksona.

Changes of different type are detected in components of NADPH-dependent oxidation. The changes begin in different periods (1, 5, 15 days) after administration of valexon to the animals. In the first day the hydroxylase activity is inhibited against a background of the uridine diphosphate glucuronyl transferase activity increase and intensification of ascorbic acid excretion with urine. Five days after the uridine diphosphate glucuronyl transferase activity becomes normal, the ascorbic acid excretion remains intensified and the demethylase and hydroxylase activities increase. Fifteen days later the hydroxylase activity becomes normal, but the demthylase activity and intensity of ascorbic acid excretion are still increased.