Assuntos
Transtornos Neuróticos/sangue , Fenotiazinas/sangue , Adulto , Animais , Biotransformação , Gatos , Cães , Feminino , Humanos , Absorção Intestinal , Cinética , Masculino , Modelos Biológicos , Transtornos Neuróticos/tratamento farmacológico , Parassimpatolíticos , Fenotiazinas/uso terapêutico , Fatores SexuaisRESUMO
By using gas-chromatographic and spectrophotometric assays and adopting pharmacokinetic models of various types the pharmacokinetics of the neuroleptic azabutyron in the plasms, bile, gastric juice and urine of rabbits and rats was studied. The maximum level of azabutyron in the plasma (27 gamma/ml) was recorded 5 minutes after introduction of the drug. The amount of unchanged azabutyron passed with urine comprises 2--4 pc of the dose actually introduced, while the quantity of the agent excreted together with the bile and gastric juice was below 1 pc. The results thus obtained were subjected to electronic data processing according to the two-compartment pharmacokinetic model. It is presumed that in order to properly explain the pharmacokinetics of azabutyron some models of a greater complexity have to be used.
