RESUMO
The onset of linear IgA bullous dermatosis (LABD) is generally spontaneous, but a number of cases of LABD have been reported either following drug exposure or in association with malignancies. We describe a patient who developed a vesicular eruption shortly after an irritant dermatitis caused by the contact with a detergent containing sodium hypochlorite. Direct immunofluorescence revealed linear deposits of IgA and C3 in the epidermal basement membrane. The patient's serum contained IgA that immunoblotted a 180-kD polypeptide in extracts of human keratinocytes. The patient responded promptly to therapy with dapsone. We suggest a possible pathogenetic relationship between the chemical dermatitis and LABD in this patient.
Assuntos
Desinfetantes/efeitos adversos , Imunoglobulina A , Dermatopatias Vesiculobolhosas/induzido quimicamente , Hipoclorito de Sódio/efeitos adversos , Adulto , Membrana Basal/patologia , Complemento C3/análise , Dapsona/uso terapêutico , Dermatite Irritante/etiologia , Dermatite Irritante/patologia , Detergentes/efeitos adversos , Epiderme/patologia , Feminino , Técnica Direta de Fluorescência para Anticorpo , Antagonistas do Ácido Fólico/uso terapêutico , Humanos , Immunoblotting , Imunoglobulina A/análise , Imunoglobulina A/sangue , Queratinócitos/patologia , Dermatopatias Vesiculobolhosas/patologiaRESUMO
Fixed drug eruptions following the use of pyrazolone derivatives occurred in 4 members of the same family: a 12-year-old girl, her grandmother, and two of her great aunts. Although the pathophysiologic events leading to this type of reaction are unknown, these cases of familial occurrence suggest that genetic predisposition might be an important causal factor.
Assuntos
Toxidermias/genética , Feprazona/efeitos adversos , Criança , Feminino , Humanos , Pessoa de Meia-Idade , LinhagemRESUMO
A case of Lichen aureus in a 15-year old boy is presented. The case is particularly underlined due to lesions on both legs.
