[C-reactive protein as possible early prognostic marker of restenosis development in coronary artery stents]. / C-reaktivnyi belok kak vozmozhnyi rannii prognosticheskii marker stenozirovaniia protezov koronarnykh arterixi

AIM: To study possible link between inflammatory response of the body to stent implantation and development of instent restenosis. METHODS: C-reactive protein (CRP) was determined in 24 patients subjected to coronary stenting. Coronary angiography was repeated in 7.1-/+0.68 months after initial procedure. RESULTS: At repeat angiography positive results of stenting persisted in 18 while restenosis developed in 6 patients. All patients had increased CRP levels on days 2-3 after stenting. Day 2 CRP levels were higher in patients with than without restenosis (28-/+4.22 mg/l and 14.17-/+2.14 mg/l, respectively, p<0.05). CRP levels tended to normalize by day 5. CONCLUSION: Coronary artery stenting in patients with angina pectoris is associated with transitory elevation of CRP level. Day 2 CRP >or=24 mg/l with high degree of probability predicts restenosis in remote period.

[Role of coronary collateral circulation in the compensation of disorders of myocardial perfusion and left ventricular function in patients with newly appearing angina pectoris]. / Rol' koronarnogo kollateral'nogo krovoobrashchenia v kompensatsii narushenii perfuzii miokarda i funktsii levogo zheludochka u bol'nykh s vpervye voznikshei stenokardiei.

The myocardial perfusion and left ventricular function were evaluated by bicycle ergometry and myocardial scintigraphy in 23 patients with primary angina taking into account the status of coronary collateral circulation in response to stenotic and occlusive atherosclerosis. In addition to severe occlusive disease of the coronary bed, most patients had significant disturbances of myocardial perfusion and left ventricular function, which were detected during exercise tests. In patients with compensatory collateral circulation in the coronary bed, such disturbances were less marked than in those without anastomoses. However collateral coronary circulation cannot be regarded to be of real value as it compensates impaired perfusion incompletely, but in some cases it can result in impaired myocardial vascularization apparently due to the steal syndrome.

[Metabolic and structural characteristics of myocardial mitochondria in patient with acquired heart defects, operated on under conditions of artificial circulation]. / Metabolicheskie i strukturnye osobennosti nitokhodrii miokarda u bol'nykh priobretennymi porokami, operirovannykh v usloviiakh iskusstvennogo krovopbrashcheniia.

Considering the significance of the unity distinguishing the level of aerobic energy generation in the myocardium, the morphological integrity of the mitochondrial membranes and the regulating influence exercised upon them by the hormones and mediators of the sympathoadrenal system the authors undertook a synchronous study of these factors in patients with rheumatic heart diseases when subjected to the cardiac valves prosthetics. These factors were found to play a key role in ensuring the contractility of the myocardium, this being confirmed by the results of clinico-biochemical comparisons. In a group of patients with dissociated processes of oxidative phosphorylation and a well-marked disintegration of membranous mitochondrial structures, as well as with a low adrenalin, noradrenaline and their precursors level in the myocardium, almost as a rule, in the early post-operative period there appeared symptoms of cardiac incompetence.

[Oxidative phosphorylation, catecholamine content and contractile function of the myocardium in patients with acquired heart defects, operated on under artificial circulation]. / Okislitel'noe fosforilirovanie, soderzhanie katekholaminov, i sokratitel'naia funktsiia miokarda u bol'nykh priobretennymi porokami serdtsa, operirovannykh v usloviiakh iskusstvennogo krovoobrashcheniia

A simultaneous determination of oxidative phosphorylation, catecholamines content and contractile function of the myocardium was conducted in patients with acquired heart diseases operated under extracorporeal circulation. The degree of conjugation of the oxidative phosphorylation has been found to depend on the severity of the initial state of the patient, and on the conditions of the surgical intervention: duration of cardiopulmonary by-pass before the excision of the mitral valve, duration of cross-clamping of the aorta, and the temperature regiment of the perfusion. Besides, it has been found that the conjugated oxidative phosphorylation is associated with the presence of catecholamines in the myocardium, while the dissociation of these processes is accompanied by a sharp fall in the content of adrenalin, noradrenalin and dophamine. The established parallelism of the catecholamines content and the oxidative phosphorylation indicates the existing correlation between them, which may determine the character of the contractile function of the myocardium.