[The characteristics of oxolinic acid transport in the blood of dogs and monkeys when administered intramuscularly and perorally]. / Osobennosti transporta oksolinovoi kisloty v krovi u sobak i obez'ian pri vmutrimyshechnom i peroral'nom vvedenii.

A possibility of testing oxolynic acid (OA) transport in blood of animals by its bactericidal effect was studied experimentally on macaques and non-pedigree dogs (intramuscular and peroral administration). Kinetics of accumulation and elimination of OA and its derivatives exhibiting bactericidal effect makes it possible to predict optimum scheme of using these drugs in prevention and treatment of radiation disease.

[Modification by mesoporphyrin-IX derivatives of Chinese hamster cell damage induced by high energy helium ions and protons]. / Modifikatsiia proizvodnym mezoporfirina-IX porazhenii kletok kitaiskogo khomiachka vysokoénergeticheskimi ionami geliia i protonami.

The damaging effect of high-energy helium ions (4 GeV), protons (9 GeV), and standard radiation was different as studied on Chinese hamster cell cultures (clone 431). A possibility of increasing the survival of cells by the pre- and post-irradiation treatment with a mesoporphyrin-IX derivative was demonstrated. It is suggested that the radioprotective effect of the modifier is associated with the decreased level of aberrant mitoses.

[Radioprotective effect of superoxide dismutase and a deuteroporphyrin-IX derivative on radiation-damaged mammalian cells]. / Radiozashchitnoe deistvie superoksiddismutazy i proizvodnogo deiteroporfirina-IX na povrezhdennye radiatsiei kletki mlekopitaiushchego.

In experiments on SOC cells, using the methods of mathematical scheduling of experiment and the computer analysis of the results obtained it was shown that the radioprotective agents, superoxide dismutase and 2,4 di-(alpha-methoxyethyl)deuteroporphyrine-IX, applied in a combination, produced an independent and additive effect on survival of irradiated cells.

[The effect of taurine on the carbohydrate metabolism of diabetic animals]. / Vliianie taurina na uglevodnyi obmen diabeticheskikh zhivotnykh

A study was made of a new antidiabetic preparation--taurin in various methods of its administration to rats and rabbits with alloxan and ditisone model of diabetes. A short-term restoration of carbohydrate metabolism was seen after intraperitoneal and intravenous injection in a dose of 200 mg/kg. Oral use of aqueous taurin solution in the same dose failed to produce the desirable result. Microcapsulated taurin with acetylcellulose in the capacity of a filler given per os in a dose of 300 mg/kg restored to the normal glycogen content in the liver and leukocytes, blood and urine sugar level, and the insulin-like activity of blood plasma. Taurin (in a concentration of 3 mg/ml) possessed an insulinogenic action in experiments on fragments of the pancreas isolated from diabetia animals.