[The participation of the GABA-A and GABA-B receptors in the mechanism of the inhibition of the contractile activity in the rabbit myometrium under the influence of GABA, AOAA and fenibut]. / Uchastie GAMK-A- i GAMK-B-retseptorov v mekhanizme tormozheniia sokratitel'noi aktivnosti miometriia krolikov pod vliianiem GAMK, AOUK i fenibuta.

Experiments on isolated strips of the rabbit uterus showed the stimulating effects of small doses of GABA, AOAA and phenibut on uterine contractility, while large doses exerted the reverse (suppressing) effects. Administration of bicuculline and picrotoxin before or after the above-mentioned drugs reduced their suppressing effects on uterine muscle contractility. The data postulate the involvement of GABAA and GABAB receptors in the drugs action on the rabbit uterus.

[Comparison of the antioxidative activity of fenibut, fentolamin and ionol]. / Sravnitel'naia antiokislitel'naia aktivnost' fenibuta, fentolamina i ionola.

Phenibut and phentolamine were found to exhibit the properties of the true antioxidants in the hen egg yolk suspension and in the rat brain homogenate. The antioxidative activities of the drugs were significantly higher in the brain homogenate, while the antioxidative activity of the known antioxidant ionol was unchanged.

[The effect of neurotropic agents on the development of toxic brain edema in sexually immature animals]. / Vliianie nekotorykh neirotropnykh sredstv na razvitie toksicheskogo oteka golovnogo mozga u nepolovozrelykh zhivotnykh.

It was established on two age groups of rats that toxic brain edema in one-month-old animals is prevented by dopegit (100 mg/kg) and aminazine (2.5 mg/kg). The pharmacological correction of the brain edema in two-month-old rats is similar to that in adult animals. The central adrenergic structures play the significant role in the development of the brain edema in sexually immature animals.

[Effect of fenibut and seduxen on fetal development in the second half of pregnancy]. / Issledovanie vliianiia fenibuta i seduksena na razvitie ploda vo vtoroi polovine beremennosti.

In experiments on rats it was found that fenibut (50 mg/kg, 1/20 of LD50) during a single and repeated administration in the fetus period of pregnancy does not exert any negative effect on the maternal organism, the growth and development of the fetus. Seduxen administered in a dose of 50 mg/kg (1/80 of LD50) alone and in combination with fenibut was shown to decrease the female body weight gain and to disturb the fetus development. Following a single administration on the 17th day of pregnancy, the effect was poorly pronounced.

[Effect of gamma-aminobutyric acid and its agonists on uterine contractile activity]. / Vliianie gamma-aminomaslianoi kisloty i ee agonistov na sokratitel'nuiu aktivnosti matki.

In chronic experiments on female rabbits it was shown that GABA-receptor agonist phenibut given in small doses exerts the stimulating effect, while GABA and phenibut administered in large doses suppress the uterine contractile activity, acting probably as modulators of presynaptic release of neuromediators. Diazepam displays the regulatory effect on the uterine contractions via the postsynaptic receptor mechanisms. The data suggest the involvement of the GABAergic mechanisms in the uterine contractile function.

[Effect of etimizol on the development of cerebral edematous swelling]. / Vliianie étimizola na razvitie oteka-nabukhaniia golovnogo mozga.

It was shown in experiments on rats on models of toxic and traumatic edemas-swellings that etimizol (5 and 1 mg/kg) prevented changes in total content of water and the cerebral tissue density.

[Effect of gamma-aminobutyric acid, its agonists and antagonists on uterine smooth muscle]. / Vliianie gamma-aminomaslianoi kisloty, ee agonistov i antagonistov na gladkuiu muskulaturu matki.

Experiments on isolated strips of the rabbit uterus showed the ability of GABA, GABAA-receptor agonist (diazepam) and GABAB-receptor antagonist (phenibut) to inhibit uterine contractility. GABAA-receptor antagonist (bicuculline) had a stimulating effect on contractility. It is assumed that GABA-ergic system plays an important role in the regulation of functional inhibition of contractile activity in the rabbit uterus, with GABA agonists regarded as potential gravidoprotectors in uterine hyperactivity or threatening miscarriage.

[Effect of pyridoxine, riboflavin, potassium orotate, folic and glutamic acids on the recovery of work capacity in sexually immature rats]. / Vliianie piridoksina, riboflavina, kaliia orotata, folievoi i glutaminovoi kislot na vosstanovlenie rabotosposobnosti u nepolovozrelykh krys.

It has been shown in experiments on 3-4-week-old rats that the use of pyridoxine, riboflavin, potassium orotate, folic and glutamic acids for 30 days accelerates the recovery of the working capacity after maximal exercise, increases the content of ATP in the muscles, and reduces the blood urea content.

[Mechanism of action of fentolamin on the gastric secretion]. / K mekhanizmu deistviia fentolamina na zheludochnuiu sekretsiiu.

Thirty-three experiments were made on mongrel dogs operated on according to Basov, with the use of phentolamine, pilocarpine, atropine, histamine and their combinations. It was established that administration of histamine gives rise to an increase in gastric secretion, provided the animals are pretreated with phentolamine or with combined pilocarpine and phentolamine. Histamine-induced gastric secretion considerably decreases, provided the animals are pretreated with atropine and ceases almost completely after administration of combined atropine and phentolamine. It is concluded that the stimulating effect of phentolamine on gastric secretion is caused by an increase in the sensitivity of H2-receptors and cholinoreceptors under blockade of the alpha-adrenoreactive systems.

[Effect of neuroleptic, adreno- and cholinolytic agents on cerebral cortical function in edema]. / Vliianie neirolepticheskikh, adreno- i kholinoliticheskikh sredstv na funktsional'noe sostoianie kory mozga pri ego oteke.

Experiments on rats with experimental brain edema under water intoxication were made to study the effects of the neuroleptics aminazine and propazine, the central M-cholinoblocker amizyl and the alpha-adrenoblocker phentolamine on the time-course of the recovery of cortical electric activity after passing of the wave of Leao's spreading depression (SD). The drugs under study were demonstrated to have antiedematous properties under water intoxication and to make to a considerable degree for disorders in the processes of the recovery of cortical electrogenesis after SD. It is assumed that the action of the drugs on the electrophysiological parameters under study is associated with their effects on metabolic processes and with the presence of antiedematous properties.

[The GABA-ergic system and brain edema]. / GAMK-ergicheskaia sistema i otek golovnogo mozga.

It has been shown in rats with experimental toxic and traumatic edemas that picrotoxin (1 mg/kg) removes the antiedematous action of diazepam, phenazepam, phenibut and amizyl and reduces the action of phentolamine. When the dose of picrotoxin is minimized to 0.5 mg/kg such an effect is not observed. Prolonged daily administration of picrotoxin in a dose of 1 mg/kg results in the development of brain edema. It is recommended that GABA-positive drugs be included into a complex of treatment measures for edema.

[Effect of sodium oxybutyrate on the development of uterine hyperactivity]. / Vliianie natriia oksibutirata na razvitie giperaktivnosti matki.

Chronic experiments on ovariectomized rabbits were made to study the effect of sodium hydroxybutyrate, a gamma-hydroxybutyric acid derivative, on the myometrium. The mechanical distension of the uterine horn provoked hyperactivity. The dopamine agonist levodopa dramatically potentiated the mechanical hyperactivity of the rabbit uterus. Sodium hydroxybutyrate (800 mg/kg i.v.) significantly inhibited the mechanical and levodopa uterine hyperactivity. The most powerful inhibitory action was produced on the levodopa hyperactivity. Sodium hydroxybutyrate can be regarded as a potential gravidoprotector. It may be assumed that the dopaminergic system is involved in the development of the myometrium hyperactivity. The GABA-ergic mechanisms are likely to play a definite role in the reduction of uterine contractility.

[Effect of benzodiazepine and GABA derivatives on the energy metabolism indices in brain edema]. / Vliianie proizvodnykh benzdiazepina i GAMK na nekotorye pokazateli énergeticheskogo obmena pri oteke golovnogo mozga.

The development of toxic and traumatic brain edema in rats is accompanied by a decrease in the ATP level, in the total amount of adenyl nucleotides, the magnitude of the energy charge in the ATP-ADP-AMP system, and by an elevation in the content of AMP. Diazepam (0.5 mg/kg) and phenibut (50 mg/kg) that exert an antiedematous action reduce the amplitude of bioenergetic shifts during edema. As for piracetam (1000 mg/kg) it exhibits an insignificant effect. It is assumed that positive action of diazepam and phenibut on brain bioenergetics in edema is realized via the GABA-ergic system.

[Pharmacological correction of traumatic brain edema]. / Farmakologicheskaia korrektsiia travmaticheskogo oteka golovnogo mozga.

Experiments on rats were made to study the action of the derivatives of benzodiazepine (diazepam, 0.5 mg/kg and phenazepam, 0.1 mg/kg), and GABA (phenibut, 50 mg/kg, pantogam, 160 mg/kg, nicotinoyl-GABA, 500 mg/kg, piracetam, 1000 mg/kg) on the development of a traumatic brain edema. Diazepam, phenazepam and phenibut were demonstrated to produce a marked antiedematous action. The drugs made water content in the brain return to normal and reduced marked biochemical alterations in the brain. It is suggested that the protective action of the drug under study on the development of brain edema is linked with the action on the mediator structures and brain tissue metabolism.

[Effect of diazepam and phenazepam on Leao's depression in brain edema]. / Vliianie diazepama i fenazepama na depressiiu Leao pri oteke golovnogo mozga.

Experiments on rats with brain edema under water intoxication were made to examine the effect of the benzodiazepine tranquilizers diazepam and phenazepam on the time course of the recovery of brain electrical activity after passing the spreading Leao's depression wave. It was found that the drugs indicated possess antiedematous properties and improve brain function under these conditions. It is assumed that the drug action on the spreading depression is linked with their effect on metabolic processes in the brain and antiedematous properties.