1.
Eksp Klin Farmakol
; 74(6): 30-2, 2011.
Artigo
em Russo
| MEDLINE
| ID: mdl-21870773
RESUMO
Pharmacokinetics of the actoprotector Metaprot, an original Russian drug, has been studied in a group of healthy adult volunteers. Metaprot in capsules was administrated orally as a single dose of 250 mg. The concentration of the active substance (ethylthiobenzimidazole) in the blood serum was determined by high-performance liquid chromatography (HPLC) with UV detection. The pharmacokinetic parameters were calculated by the model-independent method. The peak concentration of ethylthiobenzimidazole in plasma was Cmax = 0.91 +/- 1.05 microg/ml and the average time to peak concentration was t(max) = 1.06 +/- 0.16 h. A polymodal character of the distribution of pharmacokinetic parameters in the test group was revealed.
Assuntos
Benzimidazóis/administração & dosagem , Benzimidazóis/farmacocinética , Administração Oral , Adulto , Área Sob a Curva , Benzimidazóis/sangue , Transtornos Cerebrovasculares/reabilitação , Cromatografia Líquida de Alta Pressão/métodos , Relação Dose-Resposta a Droga , Feminino , Humanos , Masculino , Federação Russa , Transtornos Somatoformes/reabilitação , Adulto Jovem
2.
Voen Med Zh
; 328(11): 15-9, 2007 Nov.
Artigo
em Russo
| MEDLINE
| ID: mdl-18306707