[STUDY OF THE POSSIBILITY OF USING SILICON DIOXIDE, OBTAINED FROM METAL MANGANESE PRODUCTION WASTE, IN THE PRODUCTION OF COSMETIC CREAMS AND OINTMENTS].

The aim of the study was to study the possibility of using silicon dioxide(size 0.05 mm, purity 96-97%), obtained from metal manganese production waste, in the formulation of cosmetic creams and ointments. Silicon is a chemical element that is the second most abundant element on earth, surpassed only by oxygen in quantity. By the degree of prevalence in the human body, it is in third place. Silicon is part of collagen - the main protein of connective tissue in living organisms, including humans. The highest concentration of silicon in the human body is found in the surface of the skin, hair and nails. It actively participates in various biogenic processes, ensuring the bonding of collagen separate fibers and elastin and giving the connective tissue strength and elasticity. The degradation of collagen and elastin, the decrease in the amount of out cellular matrix proteins and fibroblasts, are associated with a decrease in the level of silicon in the connective tissue, i.e., it actually contributes to the initial stage of aging.Silicon dioxide and its organic compounds are widely used in cosmetic products, such as powders, masks, creams, peels and hair care products. Judging by the obtained results, cosmetic substances, containing silicon dioxide and plant substances have a sufficiently high colloidal and thermal stability, good osmotic properties, are easily spread, and are capable of penetrating into the agar-agar medium. It can be concluded, the silicon dioxide obtained from wastes from the production of metallic manganese, it is possible and appropriate in the production of cosmetic creams and ointments.

[ON THE USE OF AKHTAL'S THERAPEUTIC MUD IN COSMETICS AND COSMECEUTICALS].

The aim of the study was to develop cosmetic and cosmeceutical systems with sufficient stability, сontaining the therapeutic mud Akhtala. On the basis of previous experiments as the basis for obtaining creams in most cases were used distilled monoglycerides, emulsion wax, vegetable oils, cetylpalmitate, stearin, purified beeswax, carbomer 940, glycerin, demineralized water. We studied the process of solubilization of the base with the terapeutic mud, with the amount of lipophilic substances, extracted from the mud, with a number of plant extracts (in the form of dry, aqueous, and glycerin extracts), with some plant oils, organic acids and some other substances, used in cosmetic and cosmeceutical creams. When studying the stability of the developed systems,the centrifugation for 5 minutes at a rotor speed of 6000 rpm was used as the main test. The thermal stability was also studied . Based on the obtained results , the possible concentrations of the above biologically active substances in similar systems without their structural damage are determined . This makes it possible to use the primary data in the development of the formulation of a number of cosmetic and cosmeceutical products, containing the mud Akhtala. It is possible to use in the recipe a number of cosmetic and cosmeceutical remedies both the mud Akhtala and oil extracts from it.

DEVELOPMENT OF THE POWDER FORMULAS FOR ACNE TREATMENT.

Given the large enough area of the spread of acne disease, research is needed on the development of the new versions of preparations. Cosmetics and cosmeceuticals of daily use are easy to consume as preventive remedies during mild form of the disease at an early stage. These remedies include powders, which women tend to use every day, and men, if necessary, but quite often. Powder should fit the skin, not be crumbled during the air disturbance and be kept on the face for a relatively long time, have hygroscopicity, that is, they should absorb the sweat and fat. When developing formula of similar powder, we used the available literature data on remedies using for the treatment of acne. There have been studied some technological and rheological properties of powders, such the bulk specific gravity, bulk density and natural angle of slope. Given that all parameters depend on the dispersion and a specific surface of powder, the shape of the particles and their size distributions, we used the particles of all ingredients with a size of 3 to 20 µm. The obtained powder samples are easily applied to the skin, keeping on it for at least 4-5 hours. When applied to the oily skin, there are not observed swelling of starch and coating of pores, as well as the formation of a colloidal structure of bentonite clay. For the first time, a new formula is proposed for acne treating powders containing both plant and mineral components, determining both the structural features of powder and those features that are involved in certain processes that help to increase the pharmacological effect.

CREATION OF OINTMENT COMPOSITIONS CONTAINING PHENOL COMPOUNDS FOR MEDICAL TREATMENT.

The research was aimed at studying the possibility of obtaining drug ointments with a potential anti-mycotic activity by using thick extracts obtained from the leaves of fustic, hazel, nut and bark of the oak. There were prepared the ointment compositions on different bases. As a methodology for studying the properties of the obtained ointments, there have been used the studies of colloidal stability and resorption of tanning substances in agar. The obtained results allow for making conclusion that the selected ointments are colloidally stable, and the values of movement of zones of biologically active substances in the agar body are large enough. These data allow for forecasting both the possibility of creating the similar ointment systems and their rather high properties. Based on the obtained data, there have been selected the ointment composition variants for further studies.

[Development of quantitative analyse method for determination of alkaloid cytisin in Spartium junceum L., growing in Georgia].

The aim of the research was to develop a method for quantitative determination of cytisine in Spartium junceum L. We used the above-ground parts of plants. In developing a method of analysis we used the method of 3-phase extraction. In this case the best results were obtained in the system: chopped raw material - water solution of ammonia - chloroform. In this case, the amount of alkaloids extracted almost entirely from the plant and goes into the chloroform phase. Evaluation of the results was carried out by the validation. The method for determination of cytisine in raw product was proposed. The method comprises the following steps-extraction of raw materials extracting chloroform phase and its evaporation, the translation of solids in methanol, the chromatographic separation cytisine and its fixation of the spectrophotometer method. The method is reproducible, has the required accuracy, is easy to analysis (less than 9 hours).

[Biopharmaceutic and technological investigation of vagina suppositories containing brilliant green].

The vaginal suppository composition, containing 0, 05, 0, 1 and 0, 5 of drug substance is presented. The release of drug substance was investigated. The influence of a number of the factors on the degree of release was investigated. Cocoa oil, confectionery fat and three different types of emulgator were used. According to gained results the average release degree was 73-76%, which is sufficient for effective action of a preparation. The technological parameters of suppositories including the temperature melting and hardening are determined. All parameters were at an acceptable level. The optimum composition of suppositories was determined. The optimal composition of suppositories was determined (base, emulgator, the content of active substance, mass of the suppository. The investigation proved the effectiveness of the preparation.

[Antibacterial nature of medicinal ointments, based on Georgian mineral waters in treatment of generalized periodontitis].

The goal of the work was to determine antibacterial nature of the medicinal ointments (N1 - "Achtala"; N2 - "Sairme", N3 - "Tschaltubo", N4 "Amagleba") based on Georgian mineral waters and containing bio-active extracts. The goal of the work was to determine antibacterial nature of the medicinal ointments (N1 - "Achtala"; N2 - "Sairme", N3 - "Tschaltubo", N4 "Amagleba") based on Georgian mineral waters and containing bio-active extracts. The investigation was done in purpose to determine microbial structure of oral cavity of the 80 patients with chronic generalized periodontitis, as a result was confirmed, that microbial structure of these patients was rather heterogeneous and is presented by different aerobe, microaerophil and anaerobe microbial flora. The sensitivity, resistance, of isolated microorganisms, was studied to modern groups of antibiotics. Results of investigations are: high antibacterial activities of ointments, prepared on mineral waters of Georgia. So, it can be recommended for usage in treatment schedule for patients with chronic generalized periodontitis.