Estomatitis subprótesis en un consultorio médico del municipio Jaruco / Sub prosthesis Stomatitis in a doctors office from Jaruco municipality

Introducción: la estomatitis subprótesis, es una de las alteraciones más frecuentes de la mucosa bucal que se presenta en pacientes portadores de prótesis estomatológica y constituye un factor de riesgo para la aparición de lesiones premalignas y malignas de la boca. Objetivo: determinar la prevalencia de la estomatitis subprótesis en el consultorio médico número 7 del municipio Jaruco. Métodos: se realizó un estudio descriptivo transversal cuyo universo lo constituyeron 78 pacientes examinados en consulta y la muestra estuvo representada por 70 pacientes que cumplieron con los criterios de inclusión y exclusión, a los cuales se aplicó un cuestionario y se hizo un examen bucal, para conocer como se comporta esta enfermedad según edad, sexo y forma clínica, así como cuáles son los factores predisponentes que estaban presentes en esta población. Resultados: el 54,2 por ciento de la población estudiada presentó estomatitis subprótesis, de ellos el 30 por ciento perteneció a los pacientes de 60 años y mas y el sexo femenino fue el mas afectado con un 52,6 por ciento. Además el tiempo de uso de la prótesis, la higiene deficiente y las prótesis no funcionales fueron los factores que incidieron mayormente en la alta prevalencia de esta enfermedad. Conclusiones: prevaleció la estomatitis subprótesis en la población estudiada. La forma clínica grado I fue la que más se evidenció, identificándose factores predisponentes a esta afección (AU)

Introduction: sub prosthesis stomatitis, is one of the most frequent disorders of the oral mucosa that is presented in patients with dental prostheses and it constitutes a risk factor for the appearance of pre malignant lesions in the mouth. Objective: to determine the prevalence of sub prosthesis stomatitis in the Doctors Office number 7 from Jaruco municipality. Methods: a transversal descriptive study was carried out with 78 patients examined in consultation and the simple was represented by 70 patients that accomplished with the inclusion y exclusion criteria, who were applied a questionnaire and an oral exam was done, to know about this disease related to age, sex and clinical presentation as well as which are the predisposing factors that were present in this population. Results: 54,2 per cent of the studied population presented sub prosthesis stomatitis fron them the 30 per cent belonged to the patients of 60 years old and more and the female sex was the most affected with a 52,6 per cent. Besides, the time of using the prosthesis, the deficient higiene and non-functional prosthesis were the factors that most affected in the high prevalence of the disease. Conclusions: sub prosthesis stomatitis prevailed in the studied population. Grade I clinical presentation was the most evidenced identifying predisposing factors to this affection (AU)

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX loci as hematopoietic cells mature, thus coinciding with a decrease in HOX gene expression. We show that H3K79 methyltransferase activity as well as H3K79me1-to-H3K79me2 conversion is regulated by the DOT1L cofactor AF10. AF10 inactivation reverses leukemia-associated epigenetic profiles, precludes abnormal HOXA gene expression, and impairs the transforming ability of MLL-AF9, MLL-AF6, and NUP98-NSD1 fusions-mechanistically distinct HOX-activating oncogenes. Furthermore, NUP98-NSD1-transformed cells are sensitive to small-molecule inhibition of DOT1L. Our findings demonstrate that pharmacological inhibition of the DOT1L/AF10 complex may provide therapeutic benefits in an array of malignancies with abnormal HOXA gene expression.

Análisis de la asistencia a la parada cardiorrespiratoria por una Unidad Medicalizada de Emergencias / Analysis of care in cardiorespiratory arrest in an emergency medical unit

ObjetivoDescribir el perfil epidemiológico de las paradas cardiorrespiratorias (PCR) y determinar los factores asociados al éxito de las maniobras de reanimación cardiopulmonar (RCP).DiseñoEstudio observacional descriptivo retrospectivo.EmplazamientoCiudad de Badajoz y población atendida por una Unidad Medicalizada de Emergencias (UME) del Sistema Público de Salud de dicha ciudad.ParticipantesSe estudian 359 PCR reanimadas entre enero de 2002 y mayo de 2009.ResultadosDe las PCR ocurridas en adultos, el 65,4% eran varones, el 65,7% tuvieron lugar en el domicilio, en el 88% la causa fue no traumática, y en el 6% se habían realizado maniobras de RCP básica previas a la llegada de la unidad medicalizada. El porcentaje mayor de éxito se consiguió en los pacientes varones (OR: 0,43; IC 95%: 0,25-0,73; p=0,002), cuando el ritmo fue desfibrilable (OR: 0,16; IC 95%: 0,09-0,27; p<0,001) y cuando el inicio de maniobras de soporte vital avanzado (SVA) fue igual o inferior a 10 minutos (OR: 0,22; IC 95%: 0,10-0,49; p<0,001). En el análisis multivariante, el éxito se asoció de forma independiente al sexo masculino, ritmo inicial desfibrilable y tiempo de inicio de las maniobras de SVA igual o inferior a 10 minutos. Se reanimaron 9 niños, pero no se consiguió éxito en ninguno de ellos.ConclusionesLas PCR predominan en los adultos, y en pocos casos se realiza RCP previa a la llegada de la unidad de emergencias. El sexo masculino, un ritmo eléctrico desfibrilable y el inicio precoz de las maniobras de SVA, se asocian a un mayor éxito. Es escaso el número de PCR asistidas en niños y el pronóstico más desfavorable(AU)

ObjectiveTo describe the epidemiological profile of cardiac arrests and to determine factors associated with successful cardiopulmonary resuscitation (CPR).DesignRetrospective descriptive observational study.SitesBadajoz city (Spain) and population attended by the Medical Emergency Unit of the Public Health System in that city.ParticipantsA study 359 cardiac arrests resuscitated between January 2002 and May 2009.ResultsOut of the cardiac arrests that ocurred in adults, 65.40% were male, the cause was not traumatic in 88%; 65.70% occurred in the patient's home,and in 6% of the cases there had been basic life support. The higher success rate after was achieved in adult male patients (OR: 0,43; CI 95%; 0.25-0.73; P=.002), whose rhythm was shockable (OR: 0,16; CI 95%: 0,09-0,27; P<.001) and when the start time of advanced life support was equal to or less than 10minutes (OR: 0,22; CI 95%: 0,10-0,49; P<.001). In a multivariant analysis success of CPR was independently associated with male gender, initial shockable rhythm, and the onset of advanced life support within 10minutes. Nine children were revived, but success was not achieved in any.ConclusionsCardiac arrests are more common in adults and in few cases CPR is previously performed. Male gender, an initial shockable rhythm, and the early initiation of advanced life support, are associated with higher success of CPR. There were few CPR performed in cardiac arrest in children, and the prognosis was more unfavorable(AU)

[Analysis of care in cardiorespiratory arrest in an emergency medical unit]. / Análisis de la asistencia a la parada cardiorrespiratoria por una Unidad Medicalizada de Emergencias.

OBJECTIVE: To describe the epidemiological profile of cardiac arrests and to determine factors associated with successful cardiopulmonary resuscitation (CPR). DESIGN: Retrospective descriptive observational study. SITES: Badajoz city (Spain) and population attended by the Medical Emergency Unit of the Public Health System in that city. PARTICIPANTS: A study 359 cardiac arrests resuscitated between January 2002 and May 2009. RESULTS: Out of the cardiac arrests that ocurred in adults, 65.40% were male, the cause was not traumatic in 88%; 65.70% occurred in the patient's home,and in 6% of the cases there had been basic life support. The higher success rate after was achieved in adult male patients (OR: 0,43; CI 95%; 0.25-0.73; P=.002), whose rhythm was shockable (OR: 0,16; CI 95%: 0,09-0,27; P<.001) and when the start time of advanced life support was equal to or less than 10 minutes (OR: 0,22; CI 95%: 0,10-0,49; P<.001). In a multivariant analysis success of CPR was independently associated with male gender, initial shockable rhythm, and the onset of advanced life support within 10 minutes. Nine children were revived, but success was not achieved in any. CONCLUSIONS: Cardiac arrests are more common in adults and in few cases CPR is previously performed. Male gender, an initial shockable rhythm, and the early initiation of advanced life support, are associated with higher success of CPR. There were few CPR performed in cardiac arrest in children, and the prognosis was more unfavorable.