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1.
N Engl J Med ; 347(23): 1841-8, 2002 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-12466508

RESUMO

BACKGROUND: The global initiative to eradicate bancroftian filariasis currently relies on mass treatment with four to six annual doses of antifilarial drugs. The goal is to reduce the reservoir of microfilariae in the blood to a level that is insufficient to maintain transmission by the mosquito vector. METHODS: In nearly 2500 residents of Papua New Guinea, we prospectively assessed the effects of four annual treatments with a single dose of diethylcarbamazine plus ivermectin or diethylcarbamazine alone on the incidence of microfilariae-positive infections, the severity of lymphatic disease, and the rate of transmission of Wuchereria bancrofti by mosquitoes. Random assignment to treatment regimens was carried out according to the village of residence, and villages were categorized as having moderate or high rates of transmission. RESULTS: The four annual treatments with either drug regimen were taken by 77 to 86 percent of the members of the population who were at least five years old; treatments were well tolerated. The proportion with microfilariae-positive infections decreased by 86 to 98 percent, with a greater reduction in areas with a moderate rate of transmission than in those with a high rate. The respective aggregate frequencies of hydrocele and leg lymphedema were 15 percent and 5 percent before the trial began, and 5 percent (P<0.001) and 4 percent (P=0.04) after five years. Hydrocele and leg lymphedema were eliminated in 87 percent and 69 percent, respectively, of those who had these conditions at the outset. The rate of transmission by mosquitoes decreased substantially, and new microfilariae-positive infections in children were almost completely prevented over the five-year study period. CONCLUSIONS: Annual mass treatment with drugs such as diethylcarbamazine can virtually eliminate the reservoir of microfilariae and greatly reduce the frequency of clinical lymphatic abnormalities due to bancroftian filariasis. Eradication may be possible in areas with moderate rates of transmission, but longer periods of treatment or additional control measures may be necessary in areas with high rates of transmission.


Assuntos
Dietilcarbamazina/uso terapêutico , Filariose Linfática/tratamento farmacológico , Filaricidas/uso terapêutico , Ivermectina/uso terapêutico , Adolescente , Adulto , Animais , Criança , Pré-Escolar , Culicidae/parasitologia , Dietilcarbamazina/administração & dosagem , Dietilcarbamazina/efeitos adversos , Reservatórios de Doenças , Esquema de Medicação , Quimioterapia Combinada , Filariose Linfática/epidemiologia , Filariose Linfática/prevenção & controle , Filariose Linfática/transmissão , Filaricidas/administração & dosagem , Filaricidas/efeitos adversos , Humanos , Ivermectina/efeitos adversos , Linfedema/tratamento farmacológico , Linfedema/etiologia , Masculino , Papua Nova Guiné/epidemiologia , Estudos Prospectivos , Hidrocele Testicular/tratamento farmacológico , Hidrocele Testicular/etiologia , Wuchereria bancrofti/isolamento & purificação
2.
P N G Med J ; 45(3-4): 200-5, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12968790

RESUMO

A cross-sectional malaria survey of the Pabrabuk area in the Western Highlands Province found that all 4 human malaria species were present in a single village, with an overall parasite prevalence rate of 27%. Plasmodium falciparum was the most frequently detected infection (14%) followed by P. vivax (11%), P. malariae (5%) and P. ovale (3%). 10 of the 51 infections were mixed. Anopheles punctulatus was the most frequent vector species in the area, but both An. farauti no. 6 and An. karwari were also present in low numbers. This diversity in both parasite and vector populations indicates that complex malaria patterns are found in Papua New Guinea even at the moderate transmission levels found in low-lying inter-montane valleys.


Assuntos
Malária/epidemiologia , Humanos , Papua Nova Guiné/epidemiologia
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