[Experimental steroid osteoporosis in rats and the way to restore the bone tissue structure].

Experimental prednisolone administration has been shown to cause osteoporosis in animals. A single administration of fetal tissue--10-day fetal homogeneous tissue at a dose of 0.5 mg into the experimental animal femur improves the bone tissue structure, hastens its remodeling, contributes to elimination of the bone tissue pathologic process in osteoporosis.

[Protective and restorative effect of antioxidants in experimental intoxication with chlorophenols].

Experimental studies proved that ortho-chlorophenol intoxication is manifested by increased serum markers of cytolysis (alanine aminotransferase, aspartate aminotransferase) and cholestasis (alkaline phosphatase), intensified lipid peroxidation, depressed activity of antioxidant enzymes (catalase), impaired liver functional state. Studies covered protective efficiency of succinate oxymethyluracil and referent medication mexidol for ortho-chlorophenol poisoning.

[The influence of the actoprotectors on lipid peroxidation and erythrocyte membranes in rats poisoned with malathion ]. / Vliianie aktoprotektorov na perekisnoe okislenie lipidov i sostoianie membran éritrotsitov u krys pri otravlenii karbofosom.

Actoprotecting properties ofbemitil, tietasol in combination with atropin were studied in red cell membranes and lipid peroxidation of rats poisoned with MI in a dose 320 mg/kg (0.9 LD50). Atropin treatment showed a low effect. The addition of bemitil and tietasol normalized electric charge and osmotic resistance in red cell membranes, activity of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase and content of lipid peroxidation products--ketodienes and TBA-reacting products. Efficacy of the combined treatment is due primarily to noncholinergic mechanism of action of bemitil and tietasol--stimulation of endogenic antioxidant systems of erythron and antiradical activity (bemitil).

[Prophylactic efficiency of tietasol and oxymethyluracyl against chlorphenols exposure in experimental and real conditions]. / Profilakticheskaia éffektivnost' tietazola i oksimetiluratsila pri vozdeistvii khrorfenolov.

The authors studied protective efficiency of tietasol and oxymethyluracyl in experiments with animals exposed to 2,4-dichlorphenol and in real chlorphenol production. According to the results, oxymethyluracyl could be recommended to increase resistance against chemicals in occupational conditions.

[Use of quantitative chemical characteristics of phenol ethers in the prognostication of toxicity and MPEL in the air of work areas]. / Ispol'zovanie kvantovo-khimicheskikh kharakteristik éfirov fenola dlia prognozirovaniia toksichnosti i PDK v vozdukhe rabochei zony.

The contributors use the molecular orbital technique to present, with due account of the metabolism specificity, a quantitative description of the phenol ether inhalation toxicity and their reactivity calculated against the energy of the ether and OH- complex formation. Linear dependencies were identified between the acute and chronic action threshold, MAC and the quantum chemical values of the energy of formation. The dependencies were utilized for forecasting the toxicity and safe levels for 37 substances.