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1.
CEN Case Rep ; 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38750297

RESUMO

Tertiary lymphoid tissue (TLT) develops at sites of chronic immune stimulation, including infection, autoimmune disease, transplant rejection, and cancer. Recently, TLT has been focused on an indicator for poor renal prognosis in various kidney diseases. In cryoglobulinemic vasculitis (CV), specific glomerular and vascular lesions are seen; however, tubulointerstitial lesions are usually nonspecific. We herein report the case of a 74-year-old man with idiopathic CV with rare tubulointerstitial lesions, such as tubulointerstitial nephritis (TIN) with IgG4-positive plasma cell infiltration and TLT. To our knowledge, this is the first report identifying TLT in the kidney biopsy in a patient with CV. Glucocorticoid improved the renal outcome. The association between CV and TIN with TLT remains unknown.

2.
Intern Med ; 62(2): 261-267, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-35768220

RESUMO

There has been a significant shift in epidemiology and renal outcomes of infection-related glomerulonephritis (IRGN) in recent years. The renal prognosis of IRGN is often poor in adults, especially in the elderly and diabetics. We herein report an elderly diabetic patient with IRGN due to streptococcal infection complicated by hemophagocytic syndrome and cytomegalovirus nephritis, which is uncommon among non-transplant patients. Infection control and steroids did not recover the patient's renal function. For elderly IRGN patients with diabetes, a further investigation of the most effective treatment for related renal outcomes is needed.


Assuntos
Diabetes Mellitus , Glomerulonefrite , Linfo-Histiocitose Hemofagocítica , Infecções Estreptocócicas , Adulto , Humanos , Idoso , Citomegalovirus , Linfo-Histiocitose Hemofagocítica/complicações , Linfo-Histiocitose Hemofagocítica/diagnóstico , Glomerulonefrite/complicações , Glomerulonefrite/diagnóstico , Infecções Estreptocócicas/complicações , Infecções Estreptocócicas/diagnóstico
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