RESUMO
Anti-allergic effects (types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) were investigated on 48 h homologous passive cutaneous anaphylaxis (PCA), 2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis and picryl chloride (PC)-induced contact dermatitis in experimental animals. CM-ext showed inhibitory effects on these allergic models. Osthol isolated from CM-ext also had the inhibitory effects. These results suggested that Cnidii Monnieri Fructus might be useful as an agent for allergic diseases and that its anti-allergic effect was partially attributable to a coumarin derivative, osthol.
Assuntos
Antialérgicos/farmacologia , Cnidium/química , Cumarínicos/farmacologia , Frutas/química , Animais , Anti-Inflamatórios não Esteroides/farmacologia , Cumarínicos/química , Dermatite de Contato/patologia , Dermatite de Contato/prevenção & controle , Dinitrofluorbenzeno/antagonistas & inibidores , Dinitrofluorbenzeno/toxicidade , Difenidramina/farmacologia , Espectroscopia de Ressonância Magnética , Masculino , Camundongos , Camundongos Endogâmicos ICR , Anafilaxia Cutânea Passiva/efeitos dos fármacos , Cloreto de Picrila/antagonistas & inibidores , Cloreto de Picrila/toxicidade , Extratos Vegetais/farmacologia , Prednisolona/farmacologia , Prurido/induzido quimicamente , Ratos , Ratos Wistar , Pele/patologiaRESUMO
Antipruritic effects of 70% ethanol extract (CM-ext) of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri CUSSON, Umberifferae) were investigated. In mice, an oral administration of CM-ext (200 and 500 mg/kg) inhibited compound 48/80-induced scratching behavior without influence on spontaneous locomotion. Isopimpinellin (3) and osthol (1), coumarin derivatives isolated from CM-ext, showed an inhibitory effect on compound 48/80-induced scratching behavior.
