Non-ionic surfactant-assisted controlled release of oxyresveratrol on dendritic fibrous silica for topical applications.

We present a simple and eco-friendly method for controlled drug release using a surfactant-assisted method. Oxyresveratrol (ORES) was co-loaded with a non-ionic surfactant onto KCC-1, a dendritic fibrous silica, using an ethanol evaporation technique. The carriers were characterized using FE-SEM, TEM, XRD, N2 adsorption-desorption, FTIR, and Raman spectroscopy, and the loading and encapsulation efficiencies were assessed using TGA and DSC techniques. Contact angle and zeta potential were used to determine the surfactant arrangement and the particle charges. To investigate the effects of different surfactants (Tween 20, Tween 40, Tween 80, Tween 85, and Span 80) on ORES release, we conducted experiments under different pH and temperature conditions. Results showed that the types of surfactants, drug loading content, pH, and temperature significantly affected the drug release profile. The percentage of drug loading efficiency of the carriers was in the range of 80 %-100 %, and the release of ORES was in the order of M/KCC-1 > M/K/S80 > M/K/T40 > M/K/T20 > MK/T80 > M/K/T85 at 24 h. Furthermore, the carriers provided excellent protection for ORES against UVA and maintained its antioxidant activity. KCC-1 and Span 80 enhanced the cytotoxicity to HaCaT cells, while Tween 80 suppressed the cytotoxicity.

Modified NLC-loaded coumarin for pharmaceutical applications: the improvement of physical stability and controlled release profile.

BACKGROUND: Coumarin-6 is a lipophilic dye and is often used as a model in delivery system. OBJECTIVE: The aim of this study was to improve the nonstructured lipid carrier (NLC) system loading with lipophilic molecule, coumarin-6, and to investigate its characteristics in terms of physical stability and controlled release profile. MATERIALS AND METHODS: Initially, the selection of the coating polymer was observed. Then, the preparation of the conventional NLC-loaded coumarin-6 was compared to the modified NLC-loaded coumarin-6 via the probe sonication. The physical properties and stability were determined by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques. The release profile was established using fluorescent spectroscopic method. RESULTS AND DISCUSSION: The size and zeta potential measurement showed significant decrease in the size range of the modified NLC-loaded coumarin and the lower intensity of the surface charge compared to the NLC-loaded coumarin. The change of crystallinity observed from DSC and XRD techniques indicated the molecular dispersion of coumarin-6 in the lipid matrix of NLC. The FT-IR spectra were also proven that coumarin-6 was entrapped in the NLC molecule. The result showed comparable controlled release profile to the conventional preparation with no difference on the cytotoxicity level. CONCLUSIONS: The modified NLC delivery system, therefore, exhibited the acceptable potential as a nanocarrier.