[Morphological diagnosis of connective tissue dysplasia in patients, suffering postoperative abdominal hernia].

The results of treatment of 122 patients, to whom alloplasty for postoperative abdominal hernia (POAH) was performed, were analyzed. In 76 patients a connective tissue dysplasia (CTD) was diagnosed.Determination of a various types of collagen content in connective tissue of patients, suffering CTD, may confirm or exclude this diagnosis. Diagnostic significance has the enhancement of a collagen type III content in comparison with such of a type I by three times and more. The method of lectinohistochemical investigation of connective tissue was applied as a precision-enhancing method of a CTD diagnosis. Mosaic or diffuse loss of SNA, LABA, ConA receptors of lectins by collagen fascicles, which reflect carbohydrate determinants of dense and strong collagen fascicles, made of collagen type I, witness the CTD presence. Along with this, there was observed a lectin WGA receptors expression increase, which constitutes a marker of fascicular structures, made of collagen, predominantly type III and a lectin PNA receptors, which are revealed around vessels.

[Impact of connective tissue dysplasia on quality of life of patients, suffering postoperative abdominal hernia].

The results of treatment of 122 patients, in whom alloplasty was performed for anterior abdominal wall hernia (AAWH), were analyzed. In 76 patients the connective tissue dysplasia (CTD) was diagnosed, in 32 of them postoperative medicinal correction of CTD was done and in 44--a standard therapy. Analysis of the quality of life indices, using SF-36 questionnaire, have witnessed, that a CTD syndrome degrades trustworthy a patient's subjective perception of quality of life before the operation and in far remote postoperative period as well. There was established, that the complex therapy of CTD prescription have promoted the patients quality of life improvement up to the level, of average value in the investigation, but lower, than in a control group. Medicinal correction of CTD and complex rehabilitation of patients, suffering postoperative AAWH, which have occurred on a CTD background, need further improvement for rising of their treatment efficacy.

[Correction of a connective tissue dysplasia in the treatment of postoperative abdominal hernias].

There were analyzed the results of treatment of 112 patients, suffering postoperative abdominal hernia, in whom the anterior abdominal wall alloplasty was performed as well as postoperative pathogenetically substantiated complex therapy, taking into account the presence of a connective tissue dysplasia syndrome (CTDS) and the early and late postoperative complications prophylaxis. The peculiarities of postoperative period course and late follow-up results were studied up. Phenotypic features of CTDS were revealed in 53 (47.3%) patients, immunohistochemical features of a connective tissue dysplasia (a failed collagen type I and III ratio, manifested by increase of a collagen type III fibers quantity in 3 or more times) were revealed in 78 (69.6%) patients, in whom the processes of a collagen and its supermolecular formations synthesis were stimulated, using a magnesium orotate (Magnerot), which was prescribed in 1 g dose twice a day during 4 - 6 weeks. Application of composite nets, owing big pores, in a complex with a postoperative pathogenetically substantiated therapy conduction have positively influenced the disease course and the late follow-up results achieved.